Brivaracetam
| Brivaracetam | |
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(2S)-2-[(4R)-2-oxo- 4-propylpyrrolidin-1-yl] butanamide |
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| Identifiers | |
| PubChem | 9837243 |
| ChemSpider | 8012964  |
| ChEMBL | CHEMBL607400 |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C11H20N2O2 |
| Molar mass | 212.29 g mol−1 |
| Pharmacology | |
| Routes of administration |
Oral |
| Legal status |
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 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references |
Brivaracetam, the 4-n-propyl analog of levetiracetam, is a racetam derivative with anticonvulsant properties.[1][2] Brivaracetam is believed to act by binding to the ubiquitous synaptic vesicle protein SV2.[3] Phase II clinical trials in adult patients with refractory partial seizures were promising. Positive preliminary results from stage III trials have been recorded[4][5] , along with evidence that it is around 10 times more potent[6] for the prevention of certain types of seizure in mouse models than levetiracetam, of which it is an analogue.
[edit] References
- ^ von Rosenstiel P (2007). "Brivaracetam (UCB 34714)". Neurotherapeutics 4 (1): 84–7. doi:10.1016/j.nurt.2006.11.004. PMID 17199019.
- ^ Malawska B, Kulig K (2005). "Brivaracetam UCB". Curr Opin Investig Drugs 6 (7): 740–746. PMID 16044671.
- ^ Rogawski MA, Bazil CW (2008). "New molecular targets for antiepileptic drugs: α2δ, SV2A, and K(v)7/KCNQ/M potassium channels". Curr Neurol Neurosci Rep 8 (4): 345–352. doi:10.1007/s11910-008-0053-7. PMC 2587091. PMID 18590620. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2587091.
- ^ http://www.clinicaltrials.gov/ct2/show/NCT00464269?term=brivaracetam&rank=5
- ^ Rogawski M (2008). "Brivaracetam: a rational drug discovery success story". Br J Pharmacol 154 (8): 1555. doi:10.1038/bjp.2008.221. PMC 2518467. PMID 18552880. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2518467.
- ^ http://onlinelibrary.wiley.com/doi/10.1038/bjp.2008.198/full
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