GPR114
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| G protein-coupled receptor 114 | ||||||||
|---|---|---|---|---|---|---|---|---|
| Identifiers | ||||||||
| Symbols | GPR114; PGR27 | |||||||
| External IDs | MGI: 2685955 HomoloGene: 17828 IUPHAR: GPR114 GeneCards: GPR114 Gene | |||||||
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| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 221188 | 382045 | ||||||
| Ensembl | ENSG00000159618 | ENSMUSG00000061577 | ||||||
| UniProt | Q8IZF4 | Q3V3Z3 | ||||||
| RefSeq (mRNA) | NM_153837.1 | NM_001033468.3 | ||||||
| RefSeq (protein) | NP_722579.1 | NP_001028640.2 | ||||||
| Location (UCSC) | Chr 16: 57.58 – 57.63 Mb |
Chr 8: 94.92 – 94.94 Mb |
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| PubMed search | [1] | [2] | ||||||
Probable G-protein coupled receptor 114 is a protein that in humans is encoded by the GPR114 gene.[1][2] The gene product is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[3][4]
[edit] References
- ^ "Entrez Gene: GPR114 G protein-coupled receptor 114". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=221188.
- ^ Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584.
- ^ Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3.
- ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914. //www.ncbi.nlm.nih.gov/pmc/articles/PMC3321182/.
[edit] Further reading
- Vassilatis DK, Hohmann JG, Zeng H, et al. (2003). "The G protein-coupled receptor repertoires of human and mouse". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903–8. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517. //www.ncbi.nlm.nih.gov/pmc/articles/PMC153653/.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. //www.ncbi.nlm.nih.gov/pmc/articles/PMC403697/.
- Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
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