From Wikipedia, the free encyclopedia
Pirolate (CP-32,387) is an antihistamine drug with a tricyclic chemical structure which was patented as an antiallergen.[1][2] It was never marketed and there are very few literature references of it.[1]
[edit] Synthesis
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[edit] References
- ^ a b David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9.
- ^ Temple, Davis L. (1980). Drugs affecting the respiratory system: based on a symposium sponsored by the Division of Medicinal Chemistry, at the 175th meeting of the American Chemical Society, Anaheim, California, March 13-16, 1978. New Hope, Pa: The Society. ISBN 0-8412-0536-1.
- ^ Althuis, T. H.; Czuba, L. J.; Hess, H. J.; Kadin, S. B., 1974, DE 2418498
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Agonists: 2-Pyridylethylamine • Betahistine • Histamine • HTMT • UR-AK49
Antagonists: "1st generation": 4-Methyldiphenhydramine • Alimemazine • Antazoline • Azatadine • Bamipine • Benzatropine (Benztropine) • Bepotastine • Bromazine • Brompheniramine • Buclizine • Captodiame • Carbinoxamine • Chlorcyclizine • Chloropyramine • Chlorothen • Chlorphenamine • Chlorphenoxamine • Cinnarizine • Clemastine • Clobenzepam • Clocinizine • Cyclizine • Cyproheptadine • Dacemazine • Deptropine • Dexbrompheniramine • Dexchlorpheniramine • Dimenhydrinate • Dimetindene • Diphenhydramine • Diphenylpyraline • Doxylamine • Embramine • Etybenzatropine (Ethylbenztropine) • Etymemazine • Histapyrrodine • Homochlorcyclizine • Hydroxyethylpromethazine • Hydroxyzine • Isopromethazine • Isothipendyl • Meclozine • Mepyramine (Pyrilamine) • Mequitazine • Methafurylene • Methapyrilene • Methdilazine • Moxastine • Niaprazine • Orphenadrine • Oxatomide • Oxomemazine • Phenindamine • Pheniramine • Phenyltoloxamine • Pimethixene • Piperoxan • Promethazine • Propiomazine • Pyrrobutamine • Talastine • Thenalidine • Thenyldiamine • Thiazinamium • Thonzylamine • Tolpropamine • Tripelennamine • Triprolidine; "2nd generation": Acrivastine • Astemizole • Azelastine • Cetirizine • Clemizole • Clobenztropine • Ebastine • Emedastine • Epinastine • Ketotifen • Latrepirdine • Levocabastine • Loratadine • Mebhydrolin • Mizolastine • Olopatadine • Rupatadine • Setastine • Terfenadine; "3rd generation": Desloratadine • Fexofenadine • Levocetirizine; Miscellaneous: Tricyclic antidepressants ( Amitriptyline, Doxepin, Trimipramine, etc) • Tetracyclic antidepressants ( Mianserin, Mirtazapine, etc) • Serotonin antagonist and reuptake inhibitors ( Trazodone, Nefazodone) • Typical antipsychotics ( Chlorpromazine, Thioridazine, etc) • Atypical antipsychotics ( Clozapine, Olanzapine, Quetiapine, etc)
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