Fluspirilene

Fluspirilene

Systematic (IUPAC) name
8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	IM
Identifiers
CAS number	1841-19-6
ATC code	N05AG01
PubChem	CID 3396
IUPHAR ligand	85
DrugBank	DB04842
ChemSpider	3279 Y
UNII	C5QA4GLR9M Y
KEGG	D02629 Y
ChEMBL	CHEMBL46516 Y
Chemical data
Formula	C29H31F2N3O
Mol. mass	475.573 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C29H31F2N3O/c30-24-12-8-22(9-13-24)27(23-10-14-25(31)15-11-23)7-4-18-33-19-16-29(17-20-33)28(35)32-21-34(29)26-5-2-1-3-6-26/h1-3,5-6,8-15,27H,4,7,16-21H2,(H,32,35) Y Key:QOYHHIBFXOOADH-UHFFFAOYSA-N Y
Y(what is this?)  (verify)

Fluspirilene (Redeptin, Imap) is a diphenylbutylpiperidine antipsychotic drug, used for the treatment of schizophrenia. It is administered intramuscularly. It was discovered at Janssen Pharmaceutica in 1963.

Chemistry

• C. Janssen, NV Res. Lab., BE 633914  (1963).
• P.A.J. Janssen, U.S. Patent 3,238,216 (1966).
• P.A.J. Janssen, DE 1470125  (1963).

See also

• Typical antipsychotic
• Diphenylbutylpiperidine

References

• van Epen JH, Experience with fluspirilene (R 6218), a long-acting neuroleptic, Psychiatr Neurol Neurochir. 1970 Jul-Aug;73(4):277-84.
• Janssen PA, Niemegeers CJ, Schellekens KH, Lenaerts FM, Verbruggen FJ, van Nueten JM, Marsboom RH, Herin VV, Schaper WK., The pharmacology of fluspirilene (R 6218), a potent, long-acting and injectable neuroleptic drug, Arzneimittelforschung. 1970 Nov;20(11):1689-98.