Raclopride

Raclopride
Systematic (IUPAC) name
	3,5-dichloro-N-{[(2S)-1-ethylpyrrolidin-2-yl]methyl}-2-hydroxy-6-methoxybenzamide
Clinical data
Pregnancy cat.	?
Legal status	?
Pharmacokinetic data
Half-life	30 min
Identifiers
CAS number	84225-95-6
ATC code	None
PubChem	CID 3033769
IUPHAR ligand	94
ChemSpider	2298373
UNII	430K3SOZ7G
ChEMBL	CHEMBL8809
Chemical data
Formula	C15H20Cl2N2O3
Mol. mass	347.236 g/mol
SMILES	eMolecules & PubChem
	InChI InChI=1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m0/s1 ; Key:WAOQONBSWFLFPE-VIFPVBQESA-N ;
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Raclopride is a synthetic compound that acts as an antagonist on D2 dopamine receptors.^[1] It can be radiolabelled with the carbon-11 radioisotope and used in positron emission tomography (PET) scanning to assess the degree of dopamine binding to the D₂ Dopamine receptor. For example, one study found decreasing binding with the personality trait detachment.^[2]

[edit] References

^ C. Kohler, H. Hall, S. O. Ogren, L. Gawell (July 1985). "Specific in vitro and in vivo binding of 3H-raclopride. A potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain". Biochemical Pharmacology 34 (13): 2251–2259. doi:10.1016/0006-2952(85)90778-6. PMID 4015674.
^ Lars Farde, J. Petter Gustavsson, Erik Jönsson (February 1997). "D2 dopamine receptors and personality traits". Nature 385 (6617): 590. doi:10.1038/385590a0. PMID 9024656.

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