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Becaplermin

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Becaplermin

Clinical data
AHFS/Drugs.com	Consumer Drug Information
MedlinePlus	a699049
Pregnancy cat.	C
Legal status	Rx only
Routes	Topical
Identifiers
CAS number	165101-51-9^Y
ATC code	A01AD08 , D03AX06
DrugBank	DB00102
UNII	1B56C968OA^Y
ChEMBL	CHEMBL1201556^N
Chemical data
Formula	?
N(what is this?) (verify)

Becaplermin (brand name Regranex) is a cicatrizant, available as a topical gel.

Use for diabetic foot ulcers has been described.^[1]

It is also known as "platelet-derived growth factor BB".^[2]

Black box warning has been added the safety label to describe fivefold increase in death from cancer when three or more tubes are used.^[3]

[edit] References

^ Nagai MK, Embil JM (February 2002). "Becaplermin: recombinant platelet derived growth factor, a new treatment for healing diabetic foot ulcers". Expert Opin Biol Ther 2 (2): 211–8. doi:10.1517/14712598.2.2.211. PMID 11849120. http://informahealthcare.com/doi/abs/10.1517/14712598.2.2.211.
^ MeSH becaplermin
^ Medscape Article

[edit] External links

Regranex website

Stomatological preparations (A01)

Caries prophylactic agents

Dectaflur • Olaflur • Sodium fluoride • Sodium monofluorophosphate • Stannous fluoride

Anti-infectives and antiseptics

Amphotericin B • Benzoxonium chloride • Chlorhexidine • Chlortetracycline • Clotrimazole • Domiphen bromide • Doxycycline • Eugenol • Hexetidine • Hydrogen peroxide • Mepartricin • Metronidazole • Miconazole • Minocycline • Natamycin • Neomycin • Oxyquinoline • Polynoxylin • Sodium perborate • Tetracycline • Tibezonium iodide

Corticosteroids (Glucocorticoids)

Dexamethasone • Hydrocortisone • Triamcinolone

Other

Amlexanox • Acetylsalicylic acid • Becaplermin • Benzydamine • Epinephrine/Adrenalone

noco/cofa(c)/cogi/tumr, sysi

proc (peri), drug (A1)

Preparations for treatment of wounds and ulcers (D03)

epichlorohydrin: Cadexomer iodine • Crilanomer • Dextranomer

B5: Calcium pantothenate • Dexpanthenol

nitrate: Glyceryl trinitrate • Isosorbide dinitrate

other: Becaplermin • Enoxolone • Hyaluronic acid • Tetrachlorodecaoxide

Proteolytic enzymes

Clostridiopeptidase • Trypsin

M: INT, SF, LCT

noco(i/b/d/q/u/r/p/m/k/v/f)/cong/tumr(n/e/d), sysi/epon

proc, drug (D2/3/4/5/8/11)

v d e Growth factors

Fibroblast	FGF receptor ligands: FGF1/FGF2/FGF5 · FGF3/FGF4/FGF6 · KGF (FGF7/FGF10/FGF22) · FGF8/FGF17/FGF18 · FGF9/FGF16/FGF20 FGF homologous factors: FGF11 · FGF12 · FGF13 · FGF14 hormone-like: FGF19 · FGF21 · FGF23

EGF-like domain	TGF-α · EGF · HB-EGF

TGFβ pathway	TGF-β (TGF-β1, TGF-β2, TGF-β3)

Insulin-like	IGF-1 · IGF-2

Platelet-derived	PDGFA · PDGFB · PDGFC · PDGFD

Vascular endothelial	VEGF-A · VEGF-B · VEGF-C · VEGF-D · PGF

Other	Nerve · Hepatocyte

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

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Retrieved from "http://en.wikipedia.org/w/index.php?title=Becaplermin&oldid=458286472"

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