Atiprosin
From Wikipedia, the free encyclopedia
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| Systematic (IUPAC) name | |
| (4aR,12bS)-1-ethyl-12-methyl-4-(propan-2-yl)-1,2,3,4,4a,5,6,12b-octahydropyrazino[2',3':3,4]pyrido[1,2-a]indole | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | Uncontrolled |
| Routes | Oral |
| Identifiers | |
| CAS number | 89303-63-9  |
| ATC code | None |
| PubChem | CID 71770 |
| ChemSpider | 64808  |
| UNII | ALS52889WF |
| Chemical data | |
| Formula | C20H29N3 |
| Mol. mass | 311.46 g/mol |
| SMILES | eMolecules & PubChem |
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Atiprosin (AY-28,228) is an antihypertensive agent which acts as a selective α1-adrenergic receptor antagonist.[1][2][3][4] It also possesses some antihistamine activity, though it is some 15-fold weaker in this regard than as an alpha blocker.[3] It was never marketed.[1]
[edit] Synthesis
[edit] See also
[edit] References
- ^ a b David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9. http://books.google.com/?id=DeX7jgInYFMC&lpg=PA189&dq=atiprosin&pg=PA189#v=onepage&q.
- ^ Jirkovsky I, Santroch G, Baudy R, Oshiro G (February 1987). "Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents". Journal of Medicinal Chemistry 30 (2): 388–94. doi:10.1021/jm00385a022. PMID 3806618.
- ^ a b Grimes D, Rimele TJ, Henry DE, et al. (September 1987). "In vitro isolated tissue studies with atiprosin (AY-28,228): a new antihypertensive compound". Journal of Cardiovascular Pharmacology 10 (3): 249–58. doi:10.1097/00005344-198709000-00001. PMID 2444771.
- ^ Oshiro G, Wojdan A, Klein M, Metcalf G (September 1987). "Antihypertensive and hypotensive actions of atiprosin (AY-28,228) in rats, dogs, and monkeys". Journal of Cardiovascular Pharmacology 10 (3): 341–9. doi:10.1097/00005344-198709000-00014. PMID 2444784.
- ^ Jirkovsky, Ivo; George Santroch, Reinhardt Baudy, George Oshiro (1987). "Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents". Journal of Medical Chemistry 30 (2): 388–394. doi:10.1021/jm00385a022. PMID 3806618.
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