SKF-77,434 is a drug which acts as a selective dopamine D1 receptor partial agonist, and has stimulant and anorectic effects. Unlike other D1 agonists with higher efficacy such as SKF-81,297 and 6-Br-APB, SKF-77,434 does not maintain self-administration in animal studies, and so has been researched as a potential treatment for cocaine addiction.[1][2][3][4][5][6][7]
[edit] References
- ^ Grech, D. M.; Spealman, R. D.; Bergman, J. (1996). "Self-administration of D1 receptor agonists by squirrel monkeys". Psychopharmacology 125 (2): 97–104. doi:10.1007/BF02249407. PMID 8783382. edit
- ^ Weed, M. R.; Paul, I. A.; Dwoskin, L. P.; Moore, S. E.; Woolverton, W. L. (1997). "The relationship between reinforcing effects and in vitro effects of D1 agonists in monkeys". The Journal of pharmacology and experimental therapeutics 283 (1): 29–38. PMID 9336305. edit
- ^ Platt, D. M.; Rowlett, J. K.; Spealman, R. D. (2000). "Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434". The Journal of pharmacology and experimental therapeutics 293 (3): 1017–1026. PMID 10869406. edit
- ^ Platt, D. M.; Rowlett, J. K.; Spealman, R. D. (2001). "Modulation of cocaine and food self-administration by low- and high-efficacy D1 agonists in squirrel monkeys". Psychopharmacology 157 (2): 208–216. doi:10.1007/s002130100779. PMID 11594448. edit
- ^ Mutschler, N. H.; Bergman, J. (2002). "Effects of chronic administration of the D1 receptor partial agonist SKF 77434 on cocaine self-administration in rhesus monkeys". Psychopharmacology 160 (4): 362–370. doi:10.1007/s00213-001-0976-z. PMID 11919663. edit
- ^ Desai, R. I.; Terry, P.; Katz, J. L. (2005). "A comparison of the locomotor stimulant effects of D1-like receptor agonists in mice". Pharmacology, biochemistry, and behavior 81 (4): 843–848. doi:10.1016/j.pbb.2005.06.006. PMID 16000217. edit
- ^ Katz, J. L.; Kopajtic, T. A.; Terry, P. (2006). "Effects of dopamine D1-like receptor agonists on food-maintained operant behavior in rats". Behavioural pharmacology 17 (4): 303–309. doi:10.1097/01.fbp.0000205015.67079.f7. PMID 16914948. edit
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| Adamantanes |
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| Adenosine antagonists |
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| Alkylamines |
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| Arylcyclohexylamines |
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| Benzazepines |
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| Cholinergics |
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| Convulsants |
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| Eugeroics |
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| Oxazolines |
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| Phenethylamines |
1-(4-Methylphenyl)-2-aminobutane • 1-Phenyl-2-(piperidin-1-yl)pentan-3-one • 1-Methylamino-1-(3,4-methylenedioxyphenyl)propane • 2-Fluoroamphetamine • 2-Fluoromethamphetamine • 2-OH-PEA • 2-Phenyl-3-aminobutane • 2-Phenyl-3-methylaminobutane • 2,3-MDA • 3-Fluoroamphetamine • 3-Fluoroethamphetamine • 3-Fluoromethcathinone • 3-Methoxyamphetamine • 3-Methylamphetamine • 3,4-DMMC • 4-BMC • 4-Ethylamphetamine • 4-FA • 4-FMA • 4-MA • 4-MMA • 4-MTA • 6-FNE • Alfetamine • α-Ethylphenethylamine • Amfecloral • Amfepentorex • Amfepramone • Amidephrine • Amphetamine (Dextroamphetamine, Levoamphetamine) • Amphetaminil • Arbutamine • β-Methylphenethylamine • β-Phenylmethamphetamine • Benfluorex • Benzedrone • Benzphetamine • BDB (J) • BOH (Hydroxy-J) • BPAP • Buphedrone • Bupropion (Amfebutamone) • Butylone • Cathine • Cathinone • Chlorphentermine • Cinnamedrine • Clenbuterol • Clobenzorex • Cloforex • Clortermine • D-Deprenyl • Denopamine • Dimethoxyamphetamine • Dimethylamphetamine • Dimethylcathinone (Dimethylpropion, Metamfepramone) • Dobutamine • DOPA (Dextrodopa, Levodopa) • Dopamine • Dopexamine • Droxidopa • EBDB (Ethyl-J) • Ephedrine • Epinephrine (Adrenaline) • Epinine (Deoxyepinephrine) • Etafedrine • Ethcathinone (Ethylpropion) • Ethylamphetamine (Etilamfetamine) • Ethylnorepinephrine (Butanefrine) • Ethylone • Etilefrine • Famprofazone • Fenbutrazate • Fencamine • Fenethylline • Fenfluramine (Dexfenfluramine) • Fenmetramide • Fenproporex • Flephedrone • Fludorex • Furfenorex • Gepefrine • HMMA • Hordenine • Ibopamine • IMP • Indanylamphetamine • Isoetarine • Isoethcathinone • Isoprenaline (Isoproterenol) • L-Deprenyl (Selegiline) • Lefetamine • Lisdexamfetamine • Lophophine (Homomyristicylamine) • Manifaxine • MBDB (Methyl-J; "Eden") • MDA (Tenamfetamine) • MDBU • MDEA ("Eve") • MDMA ("Ecstasy", "Adam") • MDMPEA (Homarylamine) • MDOH • MDPR • MDPEA (Homopiperonylamine) • Mefenorex • Mephedrone • Mephentermine • Metanephrine • Metaraminol • Methamphetamine (Desoxyephedrine, Methedrine; Dextromethamphetamine, Levomethamphetamine) • Methoxamine • Methoxyphenamine • MMA • Methcathinone (Methylpropion) • Methedrone • Methoxyphenamine • Methylone • MMDA • MMDMA • MMMA • Morazone • N-Benzyl-1-phenethylamine • N,N-Dimethylphenethylamine • Naphthylamphetamine • Nisoxetine • Norepinephrine (Noradrenaline) • Norfenefrine • Norfenfluramine • Normetanephrine • Octopamine • Orciprenaline • Ortetamine • Oxilofrine • Paredrine (Norpholedrine, Oxamphetamine, Mycadrine) • PBA • PCA • PHA • Pargyline • Pentorex (Phenpentermine) • Pentylone • Phenatine • Phendimetrazine • Phenmetrazine • Phenpromethamine • Phentermine • Phenylalanine • Phenylephrine (Neosynephrine) • Phenylpropanolamine • Pholedrine • PIA • PMA • PMEA • PMMA • PPAP • Prenylamine • Propylamphetamine • Pseudoephedrine • Radafaxine • Ropinirole • Salbutamol (Albuterol; Levosalbutamol) • Sibutramine • Synephrine (Oxedrine) • Theodrenaline • Tiflorex (Flutiorex) • Tranylcypromine • Tyramine • Tyrosine • Xamoterol • Xylopropamine • Zylofuramine
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- Adamantanes: Amantadine
- Memantine
- Rimantadine; Aminotetralins: 7-OH-DPAT
- 8-OH-PBZI
- Rotigotine
- UH-232; Benzazepines: 6-Br-APB
- Fenoldopam
- SKF-38,393
- SKF-77,434
- SKF-81,297
- SKF-82,958
- SKF-83,959; Ergolines: Bromocriptine
- Cabergoline
- Dihydroergocryptine
- Lisuride
- LSD
- Pergolide; Dihydrexidine derivatives: 2-OH-NPA
- A-86,929
- Ciladopa
- Dihydrexidine
- Dinapsoline
- Dinoxyline
- Doxanthrine; Others: A-68,930
- A-77636
- A-412,997
- ABT-670
- ABT-724
- Aplindore
- Apomorphine
- Aripiprazole
- Bifeprunox
- BP-897
- CY-208,243
- Dizocilpine
- Etilevodopa
- Flibanserin
- Ketamine
- Melevodopa
- Modafinil
- Pardoprunox
- Phencyclidine
- PD-128,907
- PD-168,077
- PF-219,061
- Piribedil
- Pramipexole
- Propylnorapomorphine
- Pukateine
- Quinagolide
- Quinelorane
- Quinpirole
- RDS-127
- Ro10-5824
- Ropinirole
- Rotigotine
- Roxindole
- Salvinorin A
- SKF-89,145
- Sumanirole
- Terguride
- Umespirone
- WAY-100,635
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- Morpholines: Fenbutrazate
- Morazone
- Phendimetrazine
- Phenmetrazine; Oxazolines: 4-Methylaminorex (4-MAR, 4-MAX)
- Aminorex
- Clominorex
- Cyclazodone
- Fenozolone
- Fluminorex
- Pemoline
- Thozalinone; Phenethylamines (also amphetamines, cathinones, phentermines, etc): 2-Hydroxyphenethylamine (2-OH-PEA)
- 4-CAB
- 4-Methylamphetamine (4-MA)
- 4-Methylmethamphetamine (4-MMA)
- Alfetamine
- Amfecloral
- Amfepentorex
- Amfepramone
- Amphetamine (Dextroamphetamine
- Levoamphetamine)
- Amphetaminil
- β-Methylphenethylamine (β-Me-PEA)
- Benzodioxolylbutanamine (BDB)
- Benzodioxolylhydroxybutanamine (BOH)
- Benzphetamine
- Buphedrone
- Butylone
- Cathine
- Cathinone
- Clobenzorex
- Clortermine
- D-Deprenyl
- Dimethoxyamphetamine (DMA)
- Dimethoxymethamphetamine (DMMA)
- Dimethylamphetamine
- Dimethylcathinone (Dimethylpropion, metamfepramone)
- Ethcathinone (Ethylpropion)
- Ethylamphetamine
- Ethylbenzodioxolylbutanamine (EBDB)
- Ethylone
- Famprofazone
- Fenethylline
- Fenproporex
- Flephedrone
- Fludorex
- Furfenorex
- Hordenine
- Lophophine (Homomyristicylamine)
- Mefenorex
- Mephedrone
- Methamphetamine (Desoxyephedrine, Methedrine; Dextromethamphetamine
- Levomethamphetamine)
- Methcathinone (Methylpropion)
- Methedrone
- Methoxymethylenedioxyamphetamine (MMDA)
- Methoxymethylenedioxymethamphetamine (MMDMA)
- Methylbenzodioxolylbutanamine (MBDB)
- Methylenedioxyamphetamine (MDA, tenamfetamine)
- Methylenedioxyethylamphetamine (MDEA)
- Methylenedioxyhydroxyamphetamine (MDOH)
- Methylenedioxymethamphetamine (MDMA)
- Methylenedioxymethylphenethylamine (MDMPEA, homarylamine)
- Methylenedioxyphenethylamine (MDPEA, homopiperonylamine)
- Methylone
- Ortetamine
- Parabromoamphetamine (PBA)
- Parachloroamphetamine (PCA)
- Parafluoroamphetamine (PFA)
- Parafluoromethamphetamine (PFMA)
- Parahydroxyamphetamine (PHA)
- Paraiodoamphetamine (PIA)
- Paredrine (Norpholedrine, Oxamphetamine)
- Phenethylamine (PEA)
- Pholedrine
- Phenpromethamine
- Prenylamine
- Propylamphetamine
- Tiflorex (Flutiorex)
- Tyramine (TRA)
- Xylopropamine
- Zylofuramine; Piperazines: 2,5-Dimethoxy-4-bromobenzylpiperazine (2C-B-BZP)
- Benzylpiperazine (BZP)
- Methoxyphenylpiperazine (MeOPP, paraperazine)
- Methylbenzylpiperazine (MBZP)
- Methylenedioxybenzylpiperazine (MDBZP, piperonylpiperazine); Others: 2-Amino-1,2-dihydronaphthalene (2-ADN)
- 2-Aminoindane (2-AI)
- 2-Aminotetralin (2-AT)
- 4-Benzylpiperidine (4-BP)
- 5-IAI
- Clofenciclan
- Cyclopentamine
- Cypenamine
- Cyprodenate
- Feprosidnine
- Gilutensin
- Heptaminol
- Hexacyclonate
- Indanylaminopropane (IAP)
- Indanorex
- Isometheptene
- Methylhexanamine
- Naphthylaminopropane (NAP)
- Octodrine
- Phthalimidopropiophenone
- Propylhexedrine (Levopropylhexedrine)
- Tuaminoheptane (Tuamine)
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