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3d space filling model of benzhydryl group
Benzhydryl compounds are compounds that are "diphenylmethane" containing, i.e. two benzene rings adjoined by a single carbon. This simple definition does not include heteroaromatic ring moieties, which would complicate the situation even further. Although it may still be desired to include these for the purposes of 'completeness' they ought to be kept separate to avoid confusion.
[edit] Carboaromatic
[edit] Alcohols
[edit] Alkenes
[edit] Alkyl(amine)s
- Acyclic: (3-phenylpropylamine), tolpropamine, tolterodine
- Piperidine: desoxypipradrol, budipine[1]
- N-alkyl-4-piperidinol: penfluridol
- N-arylalkyl-piperidine: pimozide
- Tetrahydronaphthalene: tametraline (4-phenylaminotetralin), sertraline
- Tetrahydroisoquinoline: nomifensine, diclofensine "tetrahydronaphisoquinoline", dinapsoline (c.f. doxanthrine and dinoxyline)
- Pyrroloisoquinoline: JNJ-7925476
- Indanamine: Lu 19-005
- Tricyclic: 9-Aminomethyl-9,10-dihydroanthracene, phenindamine (see MPTP)
- Tetracyclic: maprotiline, dihydrexidine, butaclamol, ecopipam
- Tetrahydrobenzazepine: SKF-83959, SKF-82958, SKF-81297, SKF 38393, fenoldopam, 6-Br-APB, SCH 23390
- Piperazine: amperozide
- Triazaspiro: fluspirilene
[edit] Alkoxy compounds
- Acyclic (3°C): diphenhydramine (c.f deramciclane), orphenadrine, p-methyldiphenhydramine
- Acyclic (4°C): moxastine, Clemastine, embramine,
- Piperazine: GBR-12935, GBR 12909, DBL-583
- Tropine: benztropine, deptropine, etybenzatropine, difluoropine
- Piperidine: diphenylpyraline
- Phthalane: talopram, citalopram
- Octahedral: nefopam
- Benzdihydropyran: A-68930 (isochromene)
[edit] Amines
[edit] Hetereoaromatic
[edit] Heteroaromatic rings
[edit] Benzenes linked by a non-carbon atom
- Nitrogen: promethazine, imipramine, acepromazine, chlorpromazine, fluphenazine, mesoridazine, levomepromazine, perazine, periciazine, perphenazine, prochlorperazine, sulforidazine, thioridazine, trifluoperazine, triflupromazine, clozapine, thiethylperazine
- Indolic nitrogen: sertindole
- Oxygen: loxapine, asenapine, tyrima
[edit] Benzene and heterocycle linked through a non-carbon
[edit] References
[edit] External links
