Fenbendazole

Fenbendazole

Systematic (IUPAC) name
methyl N-(6-phenylsulfanyl-1H-benzoimidazol- 2-yl)carbamate
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	43210-67-9
ATC code	P02CA06 QP52AC13
PubChem	CID 3334
ChemSpider	3217 Y
UNII	621BVT9M36 Y
KEGG	D04140 Y
ChEMBL	CHEMBL37161 Y
Chemical data
Formula	C15H13N3O2S
Mol. mass	299.349 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C15H13N3O2S/c1-20-15(19)18-14-16-12-8-7-11(9-13(12)17-14)21-10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19) Y Key:HDDSHPAODJUKPD-UHFFFAOYSA-N Y
Y(what is this?)  (verify)

Fenbendazole (Hoechst brand names Panacur and Safe-Guard, Intervet Panacur and Panacur Rabbit) is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites including roundworms, hookworms, whipworms, the taenia species of tapeworms, pinworms, aelurostrongylus, paragonimiasis, strongyles and strongyloides and can be administered to sheep, cattle, horses, fish, dogs, cats, rabbits and seals. Drug interactions may occur if using bromsalan flukicides such as dibromsalan and tribromsalan. Abortions in cattle and death in sheep have been reported after using these medications together.

Toxicity

Despite being widely used as a dewormer in many species, toxicity has been reported. Birds (storks, pink pelicans, vultures, pigeons and doves) and reptiles (vipers, turtles and tortoises) have shown toxicity associated with bone marrow suppression, intestinal crypt cell necrosis and distal villi sloughing.^{[citation needed]} Abortions in domestic ruminants have been associated with concurrent use of anti-trematode therapeutic agents.^{[citation needed]}

Fenbendazole is poorly absorbed from the gastrointestinal tract in most species. The LD₅₀ in laboratory animals exceeds 10 g/kg when administered orally.

External links

• PetPlace Drug Library
• 3Dchem.com – Chemical structure