WAY-161503
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(Redirected from WAY-161,503)
| WAY-161503 | |
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(R)-8,9-Dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one |
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| Identifiers | |
| CAS number | 276694-95-2  |
| Properties | |
| Molecular formula | C11H11Cl2N3O |
| Molar mass | 272.13 g mol−1 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
| Infobox references |
WAY-161503 is a full agonist at the serotonin 5-HT2B and 5-HT2C receptors. Administration of WAY-161503 decreased food intake in rats, an effect mediated by its action on the 5-HT2C receptors. In addition, there was no development of tolerance with up to 15 days of treatment. However, clinical utility of WAY-161,503 may be limited as activation of the 5-HT2B receptor has been linked to pulmonary hypertension and cardiac valve problems.[1]
[edit] References
- ^ Rosenzweig-Lipson, Sharon (February 2006). "Antiobesity-like effects of the 5-HT2C receptor agonist WAY-161503". Brain Research 1073-1074: 240–251. doi:10.1016/j.brainres.2005.12.052. PMID 16430874.
