Laudexium metilsulfate

Laudexium metilsulfate

Systematic (IUPAC) name
1-[(3,4-Dimethoxyphenyl)methyl]-2-[10-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]decyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium methyl sulfate
Clinical data
Pregnancy cat.	?
Legal status	discontinued from clinical use
Routes	IV
Pharmacokinetic data
Bioavailability	100% (IV)
Identifiers
CAS number	3253-60-9 Y
ATC code	?
PubChem	CID 18618
UNII	D067KDG4NU N
Synonyms	Laudolissin
Chemical data
Formula	C54H80N2O16S2
Mol. mass	1077.35 g/mol
SMILES	eMolecules & PubChem
N (what is this?)  (verify)

Laudexium metilsulfate is a neuromuscular blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively in surgical anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Laudexium is no longer used in clinical practice, though it was introduced clinically in the early 1950s.^{[citation needed]} It has about half the potency, a slower onset of action and a duration of action much longer than that of d-tubocurarine. Because of its non-depolarizing mechanism of action, its pharmacological action could be antagonized by anticholinesterases.^{[citation needed]} However, it was the reports of significant post-operative re-curarization which essentially ensured the displacement of laudexium from clinical use.

External links

• MeSH Neuromuscular+blocking+agents