7-OH-DPAT
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| 7-OH-DPAT | |
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7-Hydroxy-N,N-dipropyl-2-aminotetralin[citation needed] |
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7-(Dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol[1] |
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| Identifiers | |
| Abbreviations | 7-OH-DPAT |
| CAS number | 74938-11-7  |
| PubChem | 1219, 6603867 (R), 23928184 (S) |
| ChemSpider | 1182  , 5036175 (R) |
| MeSH | 7-Hydroxy-2-N,N-dipropylaminotetralin |
| ChEMBL | CHEMBL285755 |
| Jmol-3D images | Image 1 Image 2 |
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| Properties | |
| Molecular formula | C16H25NO |
| Molar mass | 247.38 g mol−1 |
| Exact mass | 247.193614427 g mol-1 |
| log P | 3.653 |
| Acidity (pKa) | 10.389 |
| Basicity (pKb) | 3.608 |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references |
7-OH-DPAT is a synthetic compound that acts as a dopamine receptor agonist with reasonable selectivity for the D3 receptor subtype,[2][3][4] and low affinity for serotonin receptors, unlike its structural isomer 8-OH-DPAT.[5][6][7]
[edit] See also
[edit] References
- ^ "7-hydroxy-2-N,N-dipropylaminotetralin - PubChem Public Chemical Database". The PubChem Project. USA: National Center for Biotechnology Information. http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=1219.
- ^ Mulder TB, de Vries JB, Dijkstra D, Wiechers JW, Grol CJ, Horn AS (November 1987). "Further in vitro and in vivo studies with the putative presynaptic dopamine agonist N,N-dipropyl-7-hydroxy-2-aminotetralin". Naunyn-Schmiedeberg's Archives of Pharmacology 336 (5): 494–501. PMID 2830544.
- ^ Lévesque D, Diaz J, Pilon C, Martres MP, Giros B, Souil E, Schott D, Morgat JL, Schwartz JC, Sokoloff P (September 1992). "Identification, characterization, and localization of the dopamine D3 receptor in rat brain using 7-[3Hhydroxy-N,N-di-n-propyl-2-aminotetralin"]. Proceedings of the National Academy of Sciences of the United States of America 89 (17): 8155–9. doi:10.1073/pnas.89.17.8155. PMC 49875. PMID 1518841. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=49875.
- ^ Lévesque D (August 1996). "Aminotetralin drugs and D3 receptor functions. What may partially selective D3 receptor ligands tell us about dopamine D3 receptor functions?". Biochemical Pharmacology 52 (4): 511–8. doi:10.1016/0006-2952(96)00239-0. PMID 8759022.
- ^ Arvidsson LE, Johansson AM, Hacksell U, Nilsson JL, Svensson K, Hjorth S, Magnusson T, Carlsson A, Andersson B, Wikström H (November 1987). "(+)-cis-8-Hydroxy-1-methyl-2-(di-n-propylamino)tetralin: a potent and highly stereoselective 5-hydroxytryptamine receptor agonist". Journal of Medicinal Chemistry 30 (11): 2105–9. doi:10.1021/jm00394a029. PMID 2959776.
- ^ Malmberg A, Nordvall G, Johansson AM, Mohell N, Hacksell U (August 1994). "Molecular basis for the binding of 2-aminotetralins to human dopamine D2A and D3 receptors". Molecular Pharmacology 46 (2): 299–312. PMID 8078492.
- ^ Eltayb A, Lindblom S, Oerther S, Ahlenius S (July 2001). "Additive hypothermic effects of the 5-HT1A receptor agonist 8-OH-DPAT and the dopamine D2/3 receptor agonist 7-OH-DPAT in the rat". Acta Physiologica Scandinavica 172 (3): 205–9. doi:10.1046/j.1365-201x.2001.00858.x. PMID 11472307.
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