ACPD
From Wikipedia, the free encyclopedia
| ACPD | |
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1-Aminocyclopentane-1,3-dicarboxylic acid[1] |
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| Identifiers | |
| Abbreviations | ACPD |
| CAS number | 39026-63-6  , 56827-69-1 (1R,3S), 111900-32-4 (1S,3R) |
| PubChem | 1310, 44381972 (1S), 231345 (1R,3R), 73537 (1R,3S), 104766 (1S,3R), 6604704 (1S,3S) |
| ChemSpider | 5036967 (1S,3S)  , 201559 (1R,3R) , 66220 (1R,3S) , 94574 (1S,3R) |
| MeSH | 1-amino-1,3-dicarboxycyclopentane |
| ChEMBL | CHEMBL168278 |
| RTECS number | GY4060000 (1S,3R) |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C7H11NO4 |
| Molar mass | 173.17 g mol−1 |
| Exact mass | 173.068807845 g mol-1 |
| Appearance | White crystals |
| Solubility in water | 20 g dm-3 |
| Solubility in ethanol | 240 mg dm-3 |
| log P | -0.709 |
| Acidity (pKa) | 2.112 |
| Basicity (pKb) | 11.885 |
| Isoelectric point | 2.84 |
| Hazards | |
| GHS pictograms |  |
| GHS signal word | Warning |
| GHS hazard statements | H302, H312, H315, H319, H332, H335 |
| GHS precautionary statements | P261, P280, P305+351+338 |
| EU classification |  Xn |
| R-phrases | R20/21/22, R36/37/38 |
| S-phrases | S26, S36/37 |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references |
1-Amino-1,3-dicarboxycyclopentane (ACPD) is a chemical compound that binds to the metabotropic glutamate receptor (mGluR),[2] acting as a mGluR agonist. ACPD is a rigid analogue of the neurotransmitter glutamate and does not activate ionotropic glutamate receptors.[3] ACPD can induce convulsions in neonatal rats.[4]
[edit] References
- ^ "1-amino-1,3-dicarboxycyclopentane - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 25 March 2005. Identification and Related Records. http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=1310. Retrieved 15 October 2011.
- ^ Schoepp DD, True RA (September 1992). "1S,3R-ACPD-sensitive (metabotropic) [3H]glutamate receptor binding in membranes". Neurosci. Lett. 145 (1): 100–4. doi:10.1016/0304-3940(92)90213-Q. PMID 1461560. http://linkinghub.elsevier.com/retrieve/pii/0304-3940(92)90213-Q.
- ^ Manzoni O, Fagni L, Pin JP, Rassendren F, Poulat F, Sladeczek F, Bockaert J (July 1990). "(trans)-1-amino-cyclopentyl-1,3-dicarboxylate stimulates quisqualate phosphoinositide-coupled receptors but not ionotropic glutamate receptors in striatal neurons and Xenopus oocytes". Mol. Pharmacol. 38 (1): 1–6. PMID 2164627. http://molpharm.aspetjournals.org/cgi/pmidlookup?view=long&pmid=2164627.
- ^ McDonald JW, Fix AS, Tizzano JP, Schoepp DD (October 1993). "Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist". J. Neurosci. 13 (10): 4445–55. PMID 8410197. http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=8410197.
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