JWH-176
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| Systematic (IUPAC) name | |
| 1-([(1E)-3-pentylinden-1-ylidine]methyl)naphthalene | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | Legal |
| Identifiers | |
| ATC code | ? |
| Chemical data | |
| Formula | C25H24 |
| Mol. mass | 324.457 g/mol |
| SMILES | eMolecules & PubChem |
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JWH-176 is an analgesic drug which acts as a cannabinoid receptor agonist. Its binding affinity at the CB1 receptor is only 26.0nM, making it more potent than THC itself,[1] however JWH-176 is particularly notable in that it is a hydrocarbon containing no heteroatoms. This demonstrates that reasonably high-affinity cannabinoid binding and agonist effects can be produced by compounds with no hydrogen bonding capacity at all, relying merely on Van der Waals interactions to bind to the receptor.[2] It was discovered by, and named after, Dr. John W. Huffman.
[edit] See also
[edit] References
- ^ Huffman JW, Padgett LW. Recent Developments in the Medicinal Chemistry of Cannabimimetic Indoles, Pyrroles and Indenes. Current Medicinal Chemistry, 2005; 12: 1395-1411.
- ^ Roger Pertwee. Cannabinoids. Handbook of Experimental Pharmacology Volume 168, p 269. Springer. ISBN 3-540-22565-X
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