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Bromisoval

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Bromisoval
Systematic (IUPAC) name
(RS)-2-bromo-N-carbamoyl-3-methylbutanamide
Identifiers
CAS number 496-67-3
ATC code N05CM03
PubChem CID 2447
ChemSpider 2353 YesY
KEGG D01391 YesY
Chemical data
Formula C6H11BrN2O2 
Mol. mass 223.068 g/mol
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status  ?
Routes Oral
 YesY(what is this?)  (verify)

Bromisoval (INN; commonly known as bromvalerylurea) is a hypnotic and sedative. It is marketed over the counter in Asia under various trade names (such as brovarin[1]), usually in combination with non-steroidal anti-inflammatory drugs.

Chronic use of bromisoval has been associated with bromine poisoning.[2][3][4]

References

  1. ^ http://www.chemindustry.com -> Brovarin
  2. ^ Hashida H, Honda T, Morimoto H, Aibara Y (2001). "[A case of chronic bromvalerylurea intoxication due to habitual use of commercially available nonsteroidal anti-inflammatory drugs presenting an indefinite hyperchloremia]" (in Japanese). Nippon Ronen Igakkai Zasshi (Japanese Journal of Geriatrics) 38 (5): 700–3. PMID 11605223. 
  3. ^ Kawakami T, Takiyama Y, Yanaka I, et al. (1998). "Chronic bromvalerylurea intoxication: dystonic posture and cerebellar ataxia due to nonsteroidal anti-inflammatory drug abuse". Intern Med 37 (9): 788–91. doi:10.2169/internalmedicine.37.788. PMID 9804091. 
  4. ^ Wang YT, Yang SY, Wu VC, Wu KD, Fang CC (2005). "Pseudohyperchloraemia due to bromvalerylurea abuse". Nephrol Dial Transplant 20 (8): 1767–8. doi:10.1093/ndt/gfh945. PMID 15972320.  full text


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