Bromisoval
| Systematic (IUPAC) name | |
|---|---|
| (RS)-2-bromo-N-carbamoyl-3-methylbutanamide | |
| Identifiers | |
| CAS number | 496-67-3 |
| ATC code | N05CM03 |
| PubChem | CID 2447 |
| ChemSpider | 2353 |
| KEGG | D01391 |
| Chemical data | |
| Formula | C6H11BrN2O2 |
| Mol. mass | 223.068 g/mol |
| SMILES | eMolecules & PubChem |
|
|
| Therapeutic considerations | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Routes | Oral |
| |
Bromisoval (INN; commonly known as bromvalerylurea) is a hypnotic and sedative. It is marketed over the counter in Asia under various trade names (such as brovarin[1]), usually in combination with non-steroidal anti-inflammatory drugs.
Chronic use of bromisoval has been associated with bromine poisoning.[2][3][4]
References
- ^ http://www.chemindustry.com -> Brovarin
- ^ Hashida H, Honda T, Morimoto H, Aibara Y (2001). "[A case of chronic bromvalerylurea intoxication due to habitual use of commercially available nonsteroidal anti-inflammatory drugs presenting an indefinite hyperchloremia]" (in Japanese). Nippon Ronen Igakkai Zasshi (Japanese Journal of Geriatrics) 38 (5): 700–3. PMID 11605223.
- ^ Kawakami T, Takiyama Y, Yanaka I, et al. (1998). "Chronic bromvalerylurea intoxication: dystonic posture and cerebellar ataxia due to nonsteroidal anti-inflammatory drug abuse". Intern Med 37 (9): 788–91. doi:10.2169/internalmedicine.37.788. PMID 9804091.
- ^ Wang YT, Yang SY, Wu VC, Wu KD, Fang CC (2005). "Pseudohyperchloraemia due to bromvalerylurea abuse". Nephrol Dial Transplant 20 (8): 1767–8. doi:10.1093/ndt/gfh945. PMID 15972320. full text
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