Haloxazolam
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| Systematic (IUPAC) name | |
| 13-bromo-2-(2-fluorophenyl)-3-oxa-6,9-diazatricyclo[8.4.0.02,6]tetradeca-1(10),11,13-trien-8-one | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Pregnancy cat. | ? |
| Legal status | Schedule IV(US) |
| Routes | Oral |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | Hepatic |
| Half-life | ? |
| Excretion | Renal |
| Identifiers | |
| CAS number | 59128-97-1  |
| ATC code | None |
| PubChem | CID 3563 |
| DrugBank | DB01476 |
| ChemSpider | 3442  |
| UNII | verifiedrevid = 461766568 M448L2V8XP verifiedrevid = 461766568 |
| KEGG | D01758 |
| Chemical data | |
| Formula | C17H14BrFN2O2 |
| Mol. mass | 377.208 g/mol |
| SMILES | eMolecules & PubChem |
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Haloxazolam (marketed in Japan under the brand name Somelin), is a drug which is a benzodiazepine derivative.[1][2][3] It has similar hypnotic properties as the benzodiazepine drugs triazolam, temazepam, and flunitrazepam and as such is indicated for the treatment insomnia.[4] A study in cats comparing estazolam and haloxazolam found that haloxazolam only affects gamma motor neurons, whereas estazolam affects both alpha and gamma motor neurons.[5]
[edit] See also
[edit] References
- ^ Tanaka, E; Terada, M; Misawa, S; Wakasugi, C (1996). "Simultaneous determination of twelve benzodiazepines in human serum using a new reversed-phase chromatographic column on a 2-microns porous microspherical silica gel". Journal of Chromatography B 682 (1): 173–8. doi:10.1016/0378-4347(96)00121-1. PMID 8832439.
- ^ "Benzodiazepine Names". non-benzodiazepines.org.uk. http://www.non-benzodiazepines.org.uk/benzodiazepine-names.html. Retrieved 2009-04-05.
- ^ Guan, F; Seno, H; Ishii, A; Watanabe, K; Kumazawa, T; Hattori, H; Suzuki, O (1999). "Solid-phase microextraction and GC-ECD of benzophenones for detection of benzodiazepines in urine". Journal of analytical toxicology 23 (1): 54–61. PMID 10022210.
- ^ Tan, X; Uchida, S; Matsuura, M; Nishihara, K; Kojima, T (2003). "Long-, intermediate- and short-acting benzodiazepine effects on human sleep EEG spectra". Psychiatry and clinical neurosciences 57 (1): 97–104. doi:10.1046/j.1440-1819.2003.01085.x. PMID 12519461.
- ^ Sakai, Y (1983). "Comparative study on the effects of haloxazolam and estazolam, new sleep inducing drugs, on the alpha- and gamma-motor systems.". Japanese journal of pharmacology 33 (5): 1017–25. doi:10.1254/jjp.33.1017. PMID 6139494.
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