SLC30A4

Solute carrier family 30 (zinc transporter), member 4
Identifiers
Symbols	SLC30A4; ZNT4
External IDs	OMIM: 602095 MGI: 1345282 HomoloGene: 74984 GeneCards: SLC30A4 Gene
Gene Ontology Molecular function • zinc ion transmembrane transporter activity • cation transmembrane transporter activity Cellular component • late endosome • endosome membrane • membrane • integral to membrane • cytoplasmic membrane-bounded vesicle • cytoplasmic part Biological process • lactation • response to toxin • response to zinc ion • response to vitamin A • zinc ion homeostasis • transmembrane transport • regulation of sequestering of zinc ion • zinc ion transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7782	22785
Ensembl	ENSG00000104154	ENSMUSG00000005802
UniProt	O14863	Q148S1
RefSeq (mRNA)	NM_013309	NM_011774.2
RefSeq (protein)	NP_037441	NP_035904.2
Location (UCSC)	Chr 15: 45.77 – 45.82 Mb	Chr 2: 122.51 – 122.53 Mb
PubMed search	[1]	[2]

Zinc transporter 4 is a protein that in humans is encoded by the SLC30A4 gene.

See also

• Solute carrier family

Further reading

• Huang L, Gitschier J (1997). "A novel gene involved in zinc transport is deficient in the lethal milk mouse.". Nat. Genet. 17 (3): 292–7. doi:10.1038/ng1197-292. PMID 9354792. 
• Murgia C, Vespignani I, Cerase J, et al. (2000). "Cloning, expression, and vesicular localization of zinc transporter Dri 27/ZnT4 in intestinal tissue and cells.". Am. J. Physiol. 277 (6 Pt 1): G1231–9. PMID 10600821. 
• Küry S, Devilder MC, Avet-Loiseau H, et al. (2001). "Expression pattern, genomic structure and evaluation of the human SLC30A4 gene as a candidate for acrodermatitis enteropathica.". Hum. Genet. 109 (2): 178–85. doi:10.1007/s004390100539. PMID 11511923. 
• Bleck O, Ashton GH, Mallipeddi R, et al. (2002). "Genomic localization, organization and amplification of the human zinc transporter protein gene, ZNT4, and exclusion as a candidate gene in different clinical variants of acrodermatitis enteropathica.". Arch. Dermatol. Res. 293 (8): 392–6. doi:10.1007/s004030100246. PMID 11686514. 
• Nakano A, Nakano H, Hanada K, et al. (2002). "ZNT4 gene is not responsible for acrodermatitis enteropathica in Japanese families.". Hum. Genet. 110 (2): 201–2. doi:10.1007/s00439-001-0661-7. PMID 11935329. 
• Michalczyk AA, Allen J, Blomeley RC, Ackland ML (2002). "Constitutive expression of hZnT4 zinc transporter in human breast epithelial cells". Biochem. J. 364 (Pt 1): 105–13. PMC 1222551. PMID 11988082. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222551. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Michalczyk A, Varigos G, Catto-Smith A, et al. (2003). "Analysis of zinc transporter, hZnT4 ( Slc30A4), gene expression in a mammary gland disorder leading to reduced zinc secretion into milk". Hum. Genet. 113 (3): 202–10. doi:10.1007/s00439-003-0952-2. PMID 12743795. 
• Henshall SM, Afar DE, Rasiah KK, et al. (2003). "Expression of the zinc transporter ZnT4 is decreased in the progression from early prostate disease to invasive prostate cancer". Oncogene 22 (38): 6005–12. doi:10.1038/sj.onc.1206797. PMID 12955079. 
• Beck FW, Prasad AS, Butler CE, et al. (2004). "Differential expression of hZnT-4 in human prostate tissues". Prostate 58 (4): 374–81. doi:10.1002/pros.10344. PMID 14968438. 
• Ho LH, Ruffin RE, Murgia C, et al. (2004). "Labile zinc and zinc transporter ZnT4 in mast cell granules: role in regulation of caspase activation and NF-kappaB translocation". J. Immunol. 172 (12): 7750–60. PMID 15187159. 
• Smith JL, Xiong S, Markesbery WR, Lovell MA (2006). "Altered expression of zinc transporters-4 and -6 in mild cognitive impairment, early and late Alzheimer's disease brain". Neuroscience 140 (3): 879–88. doi:10.1016/j.neuroscience.2006.02.049. PMID 16580781.