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| Solute carrier family 2 (facilitated glucose transporter), member 9 | ||||||||
|---|---|---|---|---|---|---|---|---|
| Identifiers | ||||||||
| Symbols | SLC2A9; GLUT9; GLUTX; UAQTL2; URATv1 | |||||||
| External IDs | OMIM: 606142 MGI: 2152844 HomoloGene: 69290 GeneCards: SLC2A9 Gene | |||||||
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| RNA expression pattern | ||||||||
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| More reference expression data | ||||||||
| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 56606 | 117591 | ||||||
| Ensembl | ENSG00000109667 | ENSMUSG00000005107 | ||||||
| UniProt | Q9NRM0 | n/a | ||||||
| RefSeq (mRNA) | NM_001001290.1 | NM_001012363 | ||||||
| RefSeq (protein) | NP_001001290.1 | NP_001012363 | ||||||
| Location (UCSC) | Chr 4: 9.77 – 10.06 Mb |
Chr 5: 38.74 – 38.89 Mb |
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| PubMed search | [1] | [2] |
Solute carrier family 2, facilitated glucose transporter member 9 is a protein that in humans is encoded by the SLC2A9 gene.[1][2][3]
This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene.[3]
SLC2A9 has also recently been found to transport uric acid, and genetic variants of the transporter have been linked to increased risk of development of both hyperuricemia and gout.[4][5]
[edit] See also
[edit] References
- ^ Phay JE, Hussain HB, Moley JF (Aug 2000). "Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9)". Genomics 66 (2): 217–20. doi:10.1006/geno.2000.6195. PMID 10860667.
- ^ Manolescu AR, Augustin R, Moley K, Cheeseman C (Aug 2007). "A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity". Mol Membr Biol 24 (5-6): 455–63. doi:10.1080/09687680701298143. PMID 17710649.
- ^ a b "Entrez Gene: SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56606.
- ^ Vitart V, Rudan I, Hayward C, et al. (2008). "SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout". Nature Genetics 40 (4): 437. doi:10.1038/ng.106. PMID 18327257.
- ^ Döring A, Gieger C, Mehta D, et al. (2008). "SLC2A9 influences uric acid concentrations with pronounced sex-specific effects". Nature Genetics 40 (4): 430. doi:10.1038/ng.107. PMID 18327256.
[edit] Further reading
- Doege H, Bocianski A, Joost HG, Schürmann A (2001). "Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes.". Biochem. J.. 350 Pt 3: 771–6. PMC 1221309. PMID 10970791. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1221309.
- Shikhman AR, Brinson DC, Valbracht J, Lotz MK (2001). "Cytokine regulation of facilitated glucose transport in human articular chondrocytes.". J. Immunol. 167 (12): 7001–8. PMID 11739520.
- Mobasheri A, Neama G, Bell S, et al. (2002). "Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9.". Cell Biol. Int. 26 (3): 297–300. doi:10.1006/cbir.2001.0850. PMID 11991658.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Richardson S, Neama G, Phillips T, et al. (2003). "Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation.". Osteoarthr. Cartil. 11 (2): 92–101. doi:10.1053/joca.2002.0858. PMID 12554125.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Augustin R, Carayannopoulos MO, Dowd LO, et al. (2004). "Identification and characterization of human glucose transporter-like protein-9 (GLUT9): alternative splicing alters trafficking.". J. Biol. Chem. 279 (16): 16229–36. doi:10.1074/jbc.M312226200. PMID 14739288.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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