Naloxonazine
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| Naloxonazine | |
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Other names
NIH 10894; NSC 612113, Bis-[5-α-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)-morphinan-6-ylidene] hydrazine dihydrochloride |
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| Identifiers | |
| CAS number | 82824-01-9  |
| PubChem | 9576413 |
| IUPHAR ligand | 1677 |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C38H42N4O6 |
| Molar mass | 650.76 g mol−1 |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references |
Naloxonazine is a potent irreversible mu opioid antagonist.[1] Naloxonazine forms spontaneously in acidic solutions of naloxazone, and may be responsible for much or all of the irreversible μ opioid receptor binding displayed by the latter.[2]
[edit] See also
- Oxymorphone-3-methoxynaltrexonazine (OM-3-MNZ) a similarly structured opioid also having two complete & mirrored morphinan carbon skeletons but which is a full agonist instead.[3]
[edit] References
- ^ Naloxonazine dihydrochloride
- ^ Hahn, E. F.; Pasternak, G. W. (1982-09). "Naloxonazine, a potent, long-lasting inhibitor of opiate binding sites". Life Sciences 31 (12-13): 1385–1388. doi:10.1016/0024-3205(82)90387-3. PMID 6292633. http://www.sciencedirect.com/science/article/pii/0024320582903873. Retrieved 2011-10-18.
- ^ Image of OM-3-MNZ
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