TAS2R5

Taste receptor, type 2, member 5
Identifiers
Symbols	TAS2R5; T2R5
External IDs	OMIM: 605062 HomoloGene: 49580 IUPHAR: TAS2R5 GeneCards: TAS2R5 Gene
Gene Ontology Molecular function • taste receptor activity Cellular component • integral to membrane Biological process • signal transduction • chemosensory behavior • sensory perception of taste • detection of chemical stimulus involved in sensory perception of taste Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54429	n/a
Ensembl	ENSG00000127366	n/a
UniProt	Q9NYW4	n/a
RefSeq (mRNA)	NM_018980.2	n/a
RefSeq (protein)	NP_061853.1	n/a
Location (UCSC)	Chr 7: 141.49 – 141.49 Mb	n/a
PubMed search	[1]	n/a

Taste receptor type 2 member 5 is a protein that in humans is encoded by the TAS2R5 gene.

This gene encodes a bitter taste receptor; bitter taste receptors are members of the G protein-coupled receptor superfamily and are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless taste receptor genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes on chromosome 7 and is genetically linked to loci that influence bitter perception.

See also

• Taste receptor

Further reading

• Kinnamon SC (2000). "A plethora of taste receptors.". Neuron 25 (3): 507–10. doi:10.1016/S0896-6273(00)81054-5. PMID 10774719.
• Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction.". J. Biol. Chem. 277 (1): 1–4. doi:10.1074/jbc.R100054200. PMID 11696554.
• Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste.". Curr. Opin. Neurobiol. 12 (4): 366–71. doi:10.1016/S0959-4388(02)00345-8. PMID 12139982.
• Chandrashekar J, Hoon MA, Ryba NJ, Zuker CS (2007). "The receptors and cells for mammalian taste.". Nature 444 (7117): 288–94. doi:10.1038/nature05401. PMID 17108952.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800. //www.ncbi.nlm.nih.gov/pmc/articles/PMC16267/.
• Adler E, Hoon MA, Mueller KL, et al. (2000). "A novel family of mammalian taste receptors.". Cell 100 (6): 693–702. doi:10.1016/S0092-8674(00)80705-9. PMID 10761934.
• Chandrashekar J, Mueller KL, Hoon MA, et al. (2000). "T2Rs function as bitter taste receptors.". Cell 100 (6): 703–11. doi:10.1016/S0092-8674(00)80706-0. PMID 10761935.
• Firestein S (2000). "The good taste of genomics.". Nature 404 (6778): 552–3. doi:10.1038/35007167. PMID 10766221.
• Matsunami H, Montmayeur JP, Buck LB (2000). "A family of candidate taste receptors in human and mouse.". Nature 404 (6778): 601–4. doi:10.1038/35007072. PMID 10766242.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.
• Zhang Y, Hoon MA, Chandrashekar J, et al. (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.". Cell 112 (3): 293–301. doi:10.1016/S0092-8674(03)00071-0. PMID 12581520.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2882961/.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/.
• Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes.". Mol. Biol. Evol. 22 (3): 432–6. doi:10.1093/molbev/msi027. PMID 15496549.
• Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.". Genetics 170 (1): 313–26. doi:10.1534/genetics.104.037523. PMC 1449719. PMID 15744053. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1449719/.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.