L-694,247
From Wikipedia, the free encyclopedia
| L-694,247 | |
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(2-[5-[3-(4-methylsulphonylamino)benzyl- 1,2,4-oxadiazol-5-yl]- 1H-indole-3-yl]ethylamine) |
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| Properties | |
| Molecular formula | C20H21N5O3S |
| Molar mass | 411.48 g mol-1 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
| Infobox references |
L-694,247 is a somewhat selective 5-HT1D agonist, with a 10-fold greater affinity for the 5-HT1B receptor, and 25-fold greater affinity for the 5-HT1A receptor.[1] When L-694,247 was injected intraventricularly in dehydrated rats, it inhibited water intake. Pre-treatment with a 5-HT1D antagonist abolished this effect. Administration of L-694,247 to normally hydrated rats had no effect on water intake.[2]
[edit] References
- ^ Beer, MS (November 1993). "L-694,247: a potent 5-HT1D receptor agonist.". British Journal of Pharmacology 110 (3): 1196–200. PMID 8298808.
- ^ CASTRO-e-SILVA, E. DE (August 1997). "Effect of Third Ventricle Administration of L-694,247, a Selective 5-HT1D Receptor Agonist, on Water Intake in Rats". Pharmacology, Biochemistry and Behavior 57 (4): 749–754. doi:10.1016/S0091-3057(96)00457-1.
