GPR133
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| G protein-coupled receptor 133 | ||||||||
|---|---|---|---|---|---|---|---|---|
| Identifiers | ||||||||
| Symbols | GPR133; PGR25 | |||||||
| External IDs | OMIM: 613639 MGI: 3041203 HomoloGene: 34616 IUPHAR: GPR133 GeneCards: GPR133 Gene | |||||||
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| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 283383 | 243277 | ||||||
| Ensembl | ENSG00000111452 | ENSMUSG00000044017 | ||||||
| UniProt | Q6QNK2 | Q80T32 | ||||||
| RefSeq (mRNA) | NM_198827.3 | NM_001081342.1 | ||||||
| RefSeq (protein) | NP_942122.2 | NP_001074811.1 | ||||||
| Location (UCSC) | Chr 12: 131.44 – 131.63 Mb |
Chr 5: 129.1 – 129.2 Mb |
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| PubMed search | [1] | [2] | ||||||
Probable G-protein coupled receptor 133 is a protein that in humans is encoded by the GPR133 gene.[1][2]
This gene encodes a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[3][4]
[edit] References
- ^ "Entrez Gene: GPR114 G protein-coupled receptor 114". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=221188.
- ^ Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584.
- ^ Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3.
- ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914. //www.ncbi.nlm.nih.gov/pmc/articles/PMC3321182/.
[edit] Further reading
- Vanti WB, Nguyen T, Cheng R, et al. (2003). "Novel human G-protein-coupled receptors.". Biochem. Biophys. Res. Commun. 305 (1): 67–71. doi:10.1016/S0006-291X(03)00709-5. PMID 12732197.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.". Genomics 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/.
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