GPR45
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| G protein-coupled receptor 45 | ||||||||
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| Identifiers | ||||||||
| Symbols | GPR45; PSP24; PSP24(ALPHA); PSP24A | |||||||
| External IDs | OMIM: 604838 MGI: 2135882 HomoloGene: 5228 IUPHAR: GPR45 GeneCards: GPR45 Gene | |||||||
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| RNA expression pattern | ||||||||
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| More reference expression data | ||||||||
| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 11250 | 93690 | ||||||
| Ensembl | ENSG00000135973 | ENSMUSG00000041907 | ||||||
| UniProt | Q9Y5Y3 | Q9EQQ4 | ||||||
| RefSeq (mRNA) | NM_007227.3 | NM_053107.4 | ||||||
| RefSeq (protein) | NP_009158.3 | NP_444337.3 | ||||||
| Location (UCSC) | Chr 2: 105.86 – 105.86 Mb |
Chr 1: 42.95 – 43.04 Mb |
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| PubMed search | [1] | [2] | ||||||
Probable G-protein coupled receptor 45 is a protein that in humans is encoded by the GPR45 gene.[1][2]
This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system.[2]
[edit] References
- ^ Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF (May 1999). "Discovery of three novel orphan G-protein-coupled receptors". Genomics 56 (1): 12–21. doi:10.1006/geno.1998.5655. PMID 10036181.
- ^ a b "Entrez Gene: GPR45 G protein-coupled receptor 45". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11250.
[edit] Further reading
- Kawasawa Y, Kume K, Nakade S, et al. (2000). "Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45". Biochem. Biophys. Res. Commun. 276 (3): 952–6. doi:10.1006/bbrc.2000.3569. PMID 11027574.
- Kawasawa Y, Kume K, Izumi T, Shimizu T (2000). "Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems". Biochem. Biophys. Res. Commun. 276 (3): 957–64. doi:10.1006/bbrc.2000.3570. PMID 11027575.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/.
- Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
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