Anileridine
From Wikipedia, the free encyclopedia
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| Systematic (IUPAC) name | |
| Ethyl 1-[2-(4-aminophenyl)ethyl]-4-phenylpiperidine-4-carboxylate | |
| Clinical data | |
| AHFS/Drugs.com | monograph |
| Pregnancy cat. | ? |
| Legal status | ℞-only (CA) Schedule II (US) |
| Routes | Tablets, injection |
| Pharmacokinetic data | |
| Protein binding | > 95% |
| Metabolism | Hepatic |
| Identifiers | |
| CAS number | 144-14-9  |
| ATC code | N01AH05 |
| PubChem | CID 8944 |
| DrugBank | APRD00741 |
| ChemSpider | 8600 |
| UNII | 71Q1A3O279 |
| KEGG | D02941 |
| ChEBI | CHEBI:61203 |
| ChEMBL | CHEMBL1201347  |
| Chemical data | |
| Formula | C22H28N2O2 |
| Mol. mass | 352.47 g/mol |
| SMILES | eMolecules & PubChem |
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| Physical data | |
| Melt. point | 83 °C (181 °F) |
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Anileridine (trade name: Leritine) is a synthetic analgesic drug and is a member of the piperidine class of analgesic agents developed by Merck & Co. in the 1950s[1]. It differs from meperidine (Demerol) in that the N-methyl group of meperidine is replaced by an N-aminophenethyl group, which increases its analgesic activity.
Anileridine is no longer manufactured in the US or Canada.[2]
[edit] Administration
[edit] Pharmacokinetics
Anileridine usually takes effect within 15 minutes of either oral or intravenous administration, and lasts 2–3 hours.[4] It is mostly metabolized by the liver.
[edit] References
- ^ US Patent 2897204
- ^ "Discontinued Prescription Drug Products". Canadian Pharmacists' Association. http://www.pharmacists.ca/content/hcp/tools/drugnews/discontinued.htm. Retrieved 28 July 2008.
- ^ "Pharmaceutical Information - LERITINE". RxMed. http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20Monographs/CPS-%20%28General%20Monographs-%20L%29/LERITINE.html. Retrieved 16 June 2010.
- ^ "Anileridine Consumer Information". MedicineNet. http://www.medicinenet.com/anileridine-oral_tablet/article.htm. Retrieved 28 July 2008.
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