KML-010

KML-010
Systematic (IUPAC) name
	8-[4-(4-fluorophenyl)-4-oxobutyl]-1-methyl-1,3,8-triazaspiro[4.5]decan-4-one
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
ATC code	?
PubChem	CID 10404584
Chemical data
Formula	C18H24FN3O2
Mol. mass	333.400 g/mol
SMILES	eMolecules & PubChem
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KML-010 is a drug derived from spiperone. It functions as a highly selective 5-HT_2A receptor antagonist, with negligible affinity for the 5-HT_1A or 5-HT_2C receptors, and over 400-fold lower affinity for the D₂ receptor in comparison to spiperone.^[1]

[edit] See also

^ Glennon RA, Metwally K, Dukat M, Ismaiel AM, De los Angeles J, Herndon J, Teitler M, Khorana N (June 2002). "Ketanserin and spiperone as templates for novel serotonin 5-HT(2A) antagonists". Current Topics in Medicinal Chemistry 2 (6): 539–58. doi:10.2174/1568026023393787. PMID 12052193.

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