GPR39

G protein-coupled receptor 39
Identifiers
Symbols	GPR39; MGC149541
External IDs	OMIM: 602886 MGI: 1918361 HomoloGene: 20380 IUPHAR: GPR39 GeneCards: GPR39 Gene
Gene Ontology Molecular function • G-protein coupled receptor activity • metal ion binding Cellular component • plasma membrane • integral to plasma membrane Biological process • G-protein coupled receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2863	71111
Ensembl	ENSG00000183840	ENSMUSG00000026343
UniProt	O43194	Q9D442
RefSeq (mRNA)	NM_001508.2	NM_027677.2
RefSeq (protein)	NP_001499.1	NP_081953.2
Location (UCSC)	Chr 2: 133.17 – 133.4 Mb	Chr 1: 125.68 – 125.87 Mb
PubMed search	[1]	[2]

G-protein coupled receptor 39 is a protein that in humans is encoded by the GPR39 gene.

Further reading

• Popovics P, Stewart AJ (2011). "GPR39: A Zn2+-activated G protein-coupled receptor that regulates pancreatic, gastrointestinal and neuronal functions.". Cell. Mol. Life Sci. 68 (1): 85–95. doi:10.1007/s00018-010-0517-1. PMID 20812023. 
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Holst B, Holliday ND, Bach A, et al. (2005). "Common structural basis for constitutive activity of the ghrelin receptor family". J. Biol. Chem. 279 (51): 53806–17. doi:10.1074/jbc.M407676200. PMID 15383539. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/. 
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621. 
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1356129/. 
• Holst B, Egerod KL, Schild E, et al. (2007). "GPR39 signaling is stimulated by zinc ions but not by obestatin". Endocrinology 148 (1): 13–20. doi:10.1210/en.2006-0933. PMID 16959833. 
• Lauwers E, Landuyt B, Arckens L, et al. (2006). "Obestatin does not activate orphan G protein-coupled receptor GPR39". Biochem. Biophys. Res. Commun. 351 (1): 21–5. doi:10.1016/j.bbrc.2006.09.141. PMID 17054911. 
• Egerod KL, Holst B, Petersen PS, et al. (2007). "GPR39 splice variants versus antisense gene LYPD1: expression and regulation in gastrointestinal tract, endocrine pancreas, liver, and white adipose tissue". Mol. Endocrinol. 21 (7): 1685–98. doi:10.1210/me.2007-0055. PMID 17488974. 
• Yasuda S, Miyazaki T, Munechika K, et al. (2007). "Isolation of Zn2+ as an endogenous agonist of GPR39 from fetal bovine serum". J. Recept. Signal Transduct. Res. 27 (4): 235–46. doi:10.1080/10799890701506147. PMID 17885920.