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Sunepitron

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Sunepitron
Systematic (IUPAC) name
1-{[2-(pyrimidin-2-yl)octahydro-2H-pyrido[1,2-a]pyrazin-7-yl]methyl}pyrrolidine-2,5-dione
Clinical data
Pregnancy cat.  ?
Legal status Uncontrolled
Routes Oral
Identifiers
CAS number 148408-65-5
ATC code None
PubChem CID 9799246
ChemSpider 7975011
UNII 2GT50C8U60 YesY
KEGG D02569
ChEMBL CHEMBL380369
Chemical data
Formula C17H23N5O2 
Mol. mass 329.40 g/mol
SMILES eMolecules & PubChem

Sunepitron (CP-93,393) is a combined 5-HT1A receptor agonist and α2-adrenergic receptor antagonist.[1][2] It was previously under development by Pfizer for the treatment of depression and anxiety.[3] It made it to phase III clinical trials before being discontinued.[2][3]

[edit] Synthesis

Sunepitron synth.png

G.N. Bright, K.A. Desai, U.S. Patent 5,122,525 (1992).

[edit] See also

[edit] References

  1. ^ Goodnick PJ (July 1999). "Psychopharmacology of depression in the next millennium". CNS Spectrums 4 (7): 21–35. PMID 18438295. 
  2. ^ a b Stahl, S. M. (2000). Essential psychopharmacology: neuroscientific basis and practical application. Cambridge, UK: Cambridge University Press. ISBN 0-521-64615-4. http://books.google.com/books?id=ICztBCFFRqEC&lpg=PA306&pg=PA265#v=onepage&q=&f=false. 
  3. ^ a b Kaplan, Eliot F.; Turkington, Carol (2001). Making the antidepressant decision: how to choose the right treatment option for you and your loved ones. Chicago, Ill: Contemporary Books. ISBN 0-7373-0417-0. http://books.google.com/books?id=qVtvcsUy2U8C&lpg=PA218&pg=PA218#v=onepage&q=&f=false. 
GABAA PAMs
Others
α2δ VDCC Blockers
5-HT1A Agonists
Azapirones: Buspirone • Gepirone • Tandospirone; Others: Flesinoxan • Oxaflozane
H1 Antagonists
Diphenylmethanes: Captodiame • Hydroxyzine; Others: Brompheniramine • Chlorpheniramine • Pheniramine
CRH1 Antagonists
NK2 Antagonists
MCH1 antagonists
mGluR2/3 Agonists
mGluR5 NAMs
TSPO agonists
σ1 agonists
Others

M: PSO/PSI

dsrd (o, p, m, p, a, d, s), sysi/epon, spvo

proc(eval/thrp), drug(N5A/5B/5C/6A/6B/6D)
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