Budipine
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| Systematic (IUPAC) name | |
| 1-tert-butyl-4,4-diphenylpiperidine[1] | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 57982-78-2 |
| ATC code | N04BX03 |
| PubChem | CID 68778 |
| ChemSpider | 62021  |
| UNII | L9026OPI2Z |
| KEGG | D07306 |
| ChEMBL | CHEMBL334491 |
| Chemical data | |
| Formula | C21H27N |
| Mol. mass | 293.446 g/mol |
| SMILES | eMolecules & PubChem |
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Budipine is an antiparkinson agent.
Its mechanism of action is not well characterized.[2] It is believed to be an NMDA receptor antagonist,[3] however, promoting the synthesis of dopamine.[4]
Because it provides additional benefits relative to existing treatments, it probably does not precisely mimic the mechanism of an existing known treatment.[5]
[edit] See also
[edit] References
- ^ Martndale: The Complete Drug Reference, 35th Ed.
- ^ Reichmann H (October 2006). "Budipine in Parkinson's tremor". J. Neurol. Sci. 248 (1-2): 53–5. doi:10.1016/j.jns.2006.05.039. PMID 16784759. http://linkinghub.elsevier.com/retrieve/pii/S0022-510X(06)00235-8.
- ^ J. Kornhuber, B. Herr, J. Thome, P. Riederer. "The antiparkinsonian drug budipine binds to NMDA and sigma receptors in postmortem human brain tissue". J.Neural Transm.Suppl. 46:127-133, 1995. PMID 8821048
- ^ "umm.edu". http://www.umm.edu/patiented/articles/what_other_drugs_used_parkinsons_disease_000051_8.htm.
- ^ Przuntek H, Bittkau S, Bliesath H, et al. (May 2002). "Budipine provides additional benefit in patients with Parkinson disease receiving a stable optimum dopaminergic drug regimen". Arch. Neurol. 59 (5): 803–6. doi:10.1001/archneur.59.5.803. PMID 12020263. http://archneur.ama-assn.org/cgi/pmidlookup?view=long&pmid=12020263.
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