The class C G-protein-coupled receptors (IPR000337) are a class of G-protein coupled receptors that include the metabotropic glutamate receptors (IPR000162) and several additional receptors.[1]
Family C GPCRs have a large extracellular N-terminus which binds the orthosteric (endogenous) ligand. The shape of this domain is often likened to a clam. Several allosteric ligands to these receptors have been identified and these bind within the seven transmembrane region.
[edit] Subfamilies
[edit] Calcium-sensing receptor-related
- extracellular calcium-sensing receptor-related IPR000068
[edit] GABAB receptors
[edit] Metabotropic glutamate receptors
[edit] Taste receptors
[edit] Orphan
[edit] References
- ^ Bräuner-Osborne H, Wellendorph P, Jensen AA (2007). "Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors". Curr Drug Targets 8 (1): 169–84. doi:10.2174/138945007779315614. PMID 17266540.
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Class A:
Rhodopsin like |
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Metabolites and
signaling molecules
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Peptide
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Miscellaneous
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| Class B: Secretin like |
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Class C: Metabotropic
glutamate / pheromone |
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Class F:
Frizzled / Smoothened |
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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