Thozalinone
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| Systematic (IUPAC) name | |
| (RS)-2-(dimethylamino)-5-phenyl-1,3-oxazol-4(5H)-one | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ℞ Prescription only |
| Routes | Oral |
| Identifiers | |
| CAS number | 655-05-0 |
| ATC code | None |
| PubChem | CID 12602 |
| ChemSpider | 12082  |
| UNII | 68X5932947 |
| KEGG | D06115 |
| Chemical data | |
| Formula | C11H12N2O2 |
| Mol. mass | 204.225 g/mol |
| SMILES | eMolecules & PubChem |
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Thozalinone (Stimsen) is a psychostimulant that has been used as an antidepressant in Europe.[1][2][3][4] It has also been trialed as an anorectic.[5] Thozalinone likely acts via inducing the release of norepinephrine and dopamine as with its analogues pemoline and aminorex.[1][6][7]
[edit] See also
[edit] References
- ^ a b Greenblatt EN, Osterberg AC (July 1965). "Some pharmacologic properties of thozalinone, a new excitant". Toxicology and Applied Pharmacology 7 (4): 566–78. doi:10.1016/0041-008X(65)90042-6. PMID 4378772.
- ^ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8. http://books.google.com/?id=C3Uo1co4Wv0C&lpg=PA2539&dq=thozalinone&pg=PA2539#v=onepage&q=.
- ^ Merck index on CD-ROM: Windows. London: Chapman & Hall EPD. 1998. ISBN 0-412-82910-X.
- ^ Gallant DM, Bishop MP, Scrignar CB, Hornsby L, Moore B, Inturrisi BB (December 1966). "A double-blind study of thozalinone (C1 39,808) in depressed outpatients". Current Therapeutic Research, Clinical and Experimental 8 (12): 621–2. PMID 4962734.
- ^ Leite AC, Liepen LL, Costa VP (September 1971). "[Clinical trial of Stimsem Thozalinone in the treatment of obese patients]" (in Portuguese). Revista Brasileira De Medicina 28 (9): 475–8. PMID 5139648.
- ^ Yen-Koo HC, Balazs T (1980). "Detection of dopaminergic supersensitivity induced by neuroleptic drugs in mice". Drug and Chemical Toxicology 3 (2): 237–47. doi:10.3109/01480548009108286. PMID 6112126. http://informahealthcare.com/doi/abs/10.3109/01480548009108286.
- ^ Yen-Koo HC, Davis DA, Balazs T (1985). "Inhibition of dopaminergic agonist-induced gnawing behavior by neuroleptic drugs in mice". Drug and Chemical Toxicology 8 (6): 495–502. doi:10.3109/01480548509041072. PMID 2868876. http://informahealthcare.com/doi/abs/10.3109/01480548509041072.
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