Nafadotride

Nafadotride
	IUPAC name N-{[(2S)-1-butylpyrrolidin-2-yl]methyl}-4-cyano-1-methoxy-2-naphthamide
Identifiers
CAS number	149649-22-9
PubChem	3408722
MeSH	Nafadotride
ChEMBL	CHEMBL286252
IUPHAR ligand	44
Jmol-3D images	Image 1
	SMILES CCCCN1CCCC1CNC(=O)C2=C(C3=CC=CC=C3C(=C2)C#N)OC ;
Properties
Molecular formula	C22H27N3O2
Molar mass	365.47 g mol−1
	(verify) (what is: /?); Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
	Infobox references

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Nafadotride is a dopamine antagonist with reasonable selectivity for the D₃ subtype (9.6 times selectivity for D₃ over D₂).^[1]

[edit] References

^ Pilla M, Perachon S, Sautel F, Garrido F, Mann A, Wermuth CG, Schwartz JC, Everitt BJ, Sokoloff P. Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 agonist. Nature. 1999;400:371–375.

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