LP-44

LP-44
Systematic (IUPAC) name
	4-[2-(methylthio)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	824958-12-5
ATC code	?
PubChem	CID 11224758
Chemical data
Formula	C27H37N3OS
Mol. mass	451.666 g/mol
SMILES	eMolecules & PubChem
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LP-44 is a drug which acts as a potent and selective agonist at the 5HT₇ serotonin receptor. While LP-44 is less selective than the related compound LP-12, it has been more widely used in research and has been used to show the complex role of 5-HT₇ receptors in several aspects of brain function, including regulation of the sleep-wake cycle and roles in stress, learning and memory.^[1]^[2]^[3]^[4]

[edit] See also

[edit] References

^ Monti JM, Leopoldo M, Jantos H (August 2008). "The serotonin 5-HT7 receptor agonist LP-44 microinjected into the dorsal raphe nucleus suppresses REM sleep in the rat". Behavioural Brain Research 191 (2): 184–9. doi:10.1016/j.bbr.2008.03.025. PMID 18466985.
^ Xu Y, Zhang C, Wang R, Govindarajan SS, Barish PA, Vernon MM, Fu C, Acharya AP, Chen L, Boykin E, Yu J, Pan J, O'Donnell JM, Ogle WO (May 2011). "Corticosterone induced morphological changes of hippocampal and amygdaloid cell lines are dependent on 5-HT7 receptor related signal pathway". Neuroscience 182: 71–81. doi:10.1016/j.neuroscience.2011.02.042. PMID 21371532.
^ Monti JM (August 2011). "Serotonin control of sleep-wake behavior". Sleep Medicine Reviews 15 (4): 269–81. doi:10.1016/j.smrv.2010.11.003. PMID 21459634.
^ Costa L, Trovato C, Musumeci SA, Catania MV, Ciranna L (April 2011). "5-HT(1A) and 5-HT(7) receptors differently modulate AMPA receptor-mediated hippocampal synaptic transmission". Hippocampus. doi:10.1002/hipo.20940. PMID 21538661.

[pmid18466985-0] Monti JM, Leopoldo M, Jantos H (August 2008). "The serotonin 5-HT7 receptor agonist LP-44 microinjected into the dorsal raphe nucleus suppresses REM sleep in the rat". Behavioural Brain Research 191 (2): 184–9. doi:10.1016/j.bbr.2008.03.025. PMID 18466985.

[pmid21371532-1] Xu Y, Zhang C, Wang R, Govindarajan SS, Barish PA, Vernon MM, Fu C, Acharya AP, Chen L, Boykin E, Yu J, Pan J, O'Donnell JM, Ogle WO (May 2011). "Corticosterone induced morphological changes of hippocampal and amygdaloid cell lines are dependent on 5-HT7 receptor related signal pathway". Neuroscience 182: 71–81. doi:10.1016/j.neuroscience.2011.02.042. PMID 21371532.

[pmid21459634-2] Monti JM (August 2011). "Serotonin control of sleep-wake behavior". Sleep Medicine Reviews 15 (4): 269–81. doi:10.1016/j.smrv.2010.11.003. PMID 21459634.

[pmid21538661-3] Costa L, Trovato C, Musumeci SA, Catania MV, Ciranna L (April 2011). "5-HT(1A) and 5-HT(7) receptors differently modulate AMPA receptor-mediated hippocampal synaptic transmission". Hippocampus. doi:10.1002/hipo.20940. PMID 21538661.

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Dec	JAN	Feb
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2011	2012	2013

LP-44

[edit] See also

[edit] References

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