HHEX

Hematopoietically expressed homeobox
PDB rendering based on 2e1o.
Available structures PDB 2e1o
Identifiers
Symbols	HHEX; HEX; HMPH; HOX11L-PEN; PRH; PRHX
External IDs	OMIM: 604420 MGI: 96086 HomoloGene: 31110 GeneCards: HHEX Gene
Gene Ontology Molecular function • chromatin binding • sequence-specific DNA binding transcription factor activity • protein binding • transcription factor binding • eukaryotic initiation factor 4E binding • DNA bending activity • TBP-class protein binding • protein homodimerization activity • sequence-specific DNA binding • transcription regulatory region DNA binding • transcription regulatory region DNA binding • repressing transcription factor binding Cellular component • nucleus • cytoplasm • protein-DNA complex Biological process • negative regulation of transcription from RNA polymerase II promoter • vasculogenesis • morphogenesis of an epithelium • myeloid leukocyte differentiation • mRNA export from nucleus • cell cycle • multicellular organismal development • endoderm development • cell proliferation • response to wounding • organ morphogenesis • anterior/posterior pattern formation • negative regulation of transcription by transcription factor localization • negative regulation of transcription by competitive promoter binding • negative regulation of angiogenesis • poly(A)+ mRNA export from nucleus • interkinetic nuclear migration • hemopoiesis • positive regulation of Wnt receptor signaling pathway • B cell differentiation • thyroid gland development • forebrain development • negative regulation of vascular endothelial growth factor receptor signaling pathway • pancreas development • protein localization to nucleus • embryonic heart tube development • regulation of cell proliferation • response to peptide hormone stimulus • negative regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • embryonic organ development • primary lung bud formation • common bile duct development • gall bladder development • hepatic duct development • hepatoblast differentiation • hepatocyte differentiation • DNA conformation change Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3087	15242
Ensembl	ENSG00000152804	ENSMUSG00000024986
UniProt	Q03014	n/a
RefSeq (mRNA)	NM_002729	NM_008245.3
RefSeq (protein)	NP_002720	NP_032271.1
Location (UCSC)	Chr 10: 94.45 – 94.46 Mb	Chr 19: 37.51 – 37.52 Mb
PubMed search	[1]	[2]

Hematopoietically-expressed homeobox protein HHEX is a protein that in humans is encoded by the HHEX gene.

This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation.

Interactions

HHEX has been shown to interact with Promyelocytic leukemia protein.

Further reading

• Neidle S, Goodwin GH (1994). "A homology-based molecular model of the proline-rich homeodomain protein Prh, from haematopoietic cells". FEBS Lett. 345 (2–3): 93–8. doi:10.1016/0014-5793(94)00446-3. PMID 7911091. 
• Crompton MR, Bartlett TJ, MacGregor AD et al. (1993). "Identification of a novel vertebrate homeobox gene expressed in haematopoietic cells". Nucleic Acids Res. 20 (21): 5661–7. doi:10.1093/nar/20.21.5661. PMC 334400. PMID 1360645. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=334400. 
• Manfioletti G, Gattei V, Buratti E et al. (1995). "Differential expression of a novel proline-rich homeobox gene (Prh) in human hematolymphopoietic cells". Blood 85 (5): 1237–45. PMID 7858254. 
• Topcu Z, Mack DL, Hromas RA, Borden KL (2000). "The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis and growth control". Oncogene 18 (50): 7091–100. doi:10.1038/sj.onc.1203201. PMID 10597310. 
• Pellizzari L, D'Elia A, Rustighi A et al. (2000). "Expression and function of the homeodomain-containing protein Hex in thyroid cells". Nucleic Acids Res. 28 (13): 2503–11. doi:10.1093/nar/28.13.2503. PMC 102703. PMID 10871399. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=102703. 
• Schaefer LK, Wang S, Schaefer TS (2001). "Functional interaction of Jun and homeodomain proteins". J. Biol. Chem. 276 (46): 43074–82. doi:10.1074/jbc.M102552200. PMID 11551904. 
• Morgutti M, Demori E, Pecile V et al. (2001). "Genomic organization and chromosome mapping of the human homeobox gene HHEX". Cytogenet. Cell Genet. 94 (1–2): 30–2. doi:10.1159/000048778. PMID 11701950. 
• D'Elia AV, Tell G, Russo D et al. (2002). "Expression and localization of the homeodomain-containing protein HEX in human thyroid tumors". J. Clin. Endocrinol. Metab. 87 (3): 1376–83. doi:10.1210/jc.87.3.1376. PMID 11889211. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Topisirovic I, Culjkovic B, Cohen N et al. (2003). "The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth". EMBO J. 22 (3): 689–703. doi:10.1093/emboj/cdg069. PMC 140753. PMID 12554669. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=140753. 
• Nakagawa T, Abe M, Yamazaki T et al. (2003). "HEX acts as a negative regulator of angiogenesis by modulating the expression of angiogenesis-related gene in endothelial cells in vitro". Arterioscler. Thromb. Vasc. Biol. 23 (2): 231–7. doi:10.1161/01.ATV.0000052670.55321.87. PMID 12588764. 
• Puppin C, D'Elia AV, Pellizzari L et al. (2003). "Thyroid-specific transcription factors control Hex promoter activity". Nucleic Acids Res. 31 (7): 1845–52. doi:10.1093/nar/gkg295. PMC 152810. PMID 12655000. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=152810. 
• Bess KL, Swingler TE, Rivett AJ et al. (2003). "The transcriptional repressor protein PRH interacts with the proteasome". Biochem. J. 374 (Pt 3): 667–75. doi:10.1042/BJ20030769. PMC 1223646. PMID 12826010. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1223646. 
• George A, Morse HC, Justice MJ (2003). "The homeobox gene Hex induces T-cell-derived lymphomas when overexpressed in hematopoietic precursor cells". Oncogene 22 (43): 6764–73. doi:10.1038/sj.onc.1206822. PMID 14555989. 
• Minami T, Murakami T, Horiuchi K et al. (2004). "Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling". J. Biol. Chem. 279 (20): 20626–35. doi:10.1074/jbc.M308730200. PMID 15016828. 
• Puppin C, Presta I, D'Elia AV et al. (2004). "Functional interaction among thyroid-specific transcription factors: Pax8 regulates the activity of Hex promoter". Mol. Cell. Endocrinol. 214 (1–2): 117–25. doi:10.1016/j.mce.2003.10.061. PMID 15062550. 
• Swingler TE, Bess KL, Yao J et al. (2004). "The proline-rich homeodomain protein recruits members of the Groucho/Transducin-like enhancer of split protein family to co-repress transcription in hematopoietic cells". J. Biol. Chem. 279 (33): 34938–47. doi:10.1074/jbc.M404488200. PMID 15187083. 

External links

• MeSH HHEX+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.