Taltirelin (marketed under the tradename Ceredist) is a thyrotropin-releasing hormone (TRH) analog, which mimics the physiological actions of TRH, but with a much longer half-life and duration of effects,[1] and little development of tolerance following prolonged dosing.[2] It has nootropic,[3] neuroprotective[4] and analgesic effects,[5] and is primarily being researched for the treatment of Spinocerebellar ataxia.
[edit] References
- ^ Fukuchi I, Asahi T, Kawashima K et al (April 1998). "Effects of taltirelin hydrate (TA-0910), a novel thyrotropin-releasing hormone analog, on in vivo dopamine release and turnover in rat brain". Arzneimittelforschung 48 (4): 353–9. PMID 9608876.
- ^ Asai H, Asahi T, Yamamura M, Yamauchi-Kohno R, Saito A. Lack of behavioral tolerance by repeated treatment with taltirelin hydrate, a thyrotropin-releasing hormone analog, in rats. Pharmacology, Biochemistry and Behaviour. 2005 Dec;82(4):646-51. PMID 16368129
- ^ Yamamura M, Suzuki M, Matsumoto K. Synthesis and pharmacological action of TRH analog peptide (Taltirelin). Nippon Yakurigaku Zasshi. (Japanese). 1997 Oct;110 Suppl 1:33P-38P. PMID 9503402
- ^ Urayama A, Yamada S, Kimura R, Zhang J, Watanabe Y. Neuroprotective effect and brain receptor binding of taltirelin, a novel thyrotropin-releasing hormone (TRH) analogue, in transient forebrain ischemia of C57BL/6J mice. Life Sciences. 2002 Dec 20;72(4-5):601-7. PMID 12467901
- ^ Tanabe M, Tokuda Y, Takasu K, Ono K, Honda M, Ono H. The synthetic TRH analogue taltirelin exerts modality-specific antinociceptive effects via distinct descending monoaminergic systems. British Journal of Pharmacology. 2007 Feb;150(4):403-14. PMID 17220907
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