Tampramine
From Wikipedia, the free encyclopedia
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| Systematic (IUPAC) name | |
| N,N-dimethyl-3-(6-phenyl-11H-pyrido[2,3-b][1,4]benzodiazepin-11-yl)propan-1-amine (2E)-but-2-enedioate | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | Uncontrolled |
| Routes | Oral |
| Identifiers | |
| CAS number | 83166-18-1 |
| ATC code | None |
| PubChem | CID 6450479 |
| ChemSpider | 4953084 |
| UNII | 47GSE5RM8N  |
| Chemical data | |
| Formula | C27H28N4O4 |
| Mol. mass | 472.54 g/mol |
| SMILES | eMolecules & PubChem |
Tampramine (AHR-9,377) is a tricyclic antidepressant (TCA) which was developed in the 1980s but was never marketed.[1][2] Despite being a TCA, it acts as a selective norepinephrine reuptake inhibitor and has negligible affinity for adrenergic, histaminergic, and muscarinic receptors.[1] It was found to be effective in the forced swim test (FST) model of depression in animal studies but is not known to have ever been trialed in humans.[2]
[edit] See also
[edit] References
- ^ a b Kinnier WJ, Tabor RD, Norrell LY (October 1984). "Neurochemical properties of AHR-9377: a novel inhibitor of norepinephrine reuptake". Biochemical Pharmacology 33 (19): 3001–5. doi:10.1016/0006-2952(84)90600-2. PMID 6548381. http://linkinghub.elsevier.com/retrieve/pii/0006-2952(84)90600-2.
- ^ a b O'Donnell JM, Seiden LS (1985). "Effect of the experimental antidepressant AHR-9377 on performance during differential reinforcement of low response rate". Psychopharmacology 87 (3): 283–5. doi:10.1007/BF00432708. PMID 3936083.
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