Caroverine

Caroverine
Systematic (IUPAC) name
	1-[2-(diethylamino)ethyl]- 3-(4-methoxybenzyl)quinoxalin- 2(1H)-one
Clinical data
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Oral
Identifiers
CAS number	23465-76-1
ATC code	A03AX11
PubChem	CID 65709
ChemSpider	59135
UNII	XJ73B0K6KB
Chemical data
Formula	C22H27N3O2
Mol. mass	365.47 g/mol
SMILES	eMolecules & PubChem
	InChI InChI=1S/C22H27N3O2/c1-4-24(5-2)14-15-25-21-9-7-6-8-19(21)23-20(22(25)26)16-17-10-12-18(27-3)13-11-17/h6-13H,4-5,14-16H2,1-3H3 ; Key:MSPRUJDUTKRMLM-UHFFFAOYSA-N ;
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Caroverine (Spasmium, Spadon) is a drug used as a spasmolytic and otoneuroprotective (inner ear protective) agent in some countries.^[1] It acts as an N-type calcium channel blocker, competitive AMPA receptor antagonist, and non-competitive NMDA receptor antagonist.^[1] It also has potent antioxidant effects.^[1]^[2]

[edit] References

^ ^a ^b ^c Udilova N, Kozlov AV, Bieberschulte W, Frei K, Ehrenberger K, Nohl H (January 2003). "The antioxidant activity of caroverine". Biochemical Pharmacology 65 (1): 59–65. doi:10.1016/S0006-2952(02)01452-1. PMID 12473379.
^ Nohl H, Bieberschulte W, Dietrich B, Udilova N, Kozlov AV (2003). "Caroverine, a multifunctional drug with antioxidant functions". BioFactors 19 (1–2): 79–85. doi:10.1002/biof.5520190110. PMID 14757980.

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