Tiletamine
From Wikipedia, the free encyclopedia
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| Systematic (IUPAC) name | |
| 2-ethylamino-2-(2-thienyl) cyclohexanone | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Pregnancy cat. | ? |
| Legal status | Schedule III (US) |
| Routes | IV, IM, SC, Other |
| Pharmacokinetic data | |
| Metabolism | Liver |
| Excretion | Kidneys |
| Identifiers | |
| ATC code | None |
| PubChem | CID 26533 |
| ChemSpider | 24714  |
| UNII | 2YFC543249 |
| KEGG | D08596 |
| Chemical data | |
| Formula | C12H17NOS |
| Mol. mass | 223.34 g/mol |
| SMILES | eMolecules & PubChem |
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Tiletamine is a dissociative anesthetic and pharmacologically classified as an NMDA receptor antagonist.[1] It is related chemically and pharmacologically to other anesthetics in this family such as ketamine and phencyclidine. Tiletamine hydrochloride exists as odourless white crystals. It is used in veterinary medicine in the compound product Telazol (tiletamine/zolazepam, 50 mg/ml of each in 5 ml vial) as an injectable anesthetic for use in cats and dogs.[2] It is sometimes used in combination with xylazine (Rompun) to tranquilize large mammals such as polar bears[3] and wood bison[4]. Telazol is the only commercially available tiletamine product in the United States. It is contraindicated in patients of an ASA score of III or greater and in animals with CNS signs, hyperthyroidism, cardiac disease, pancreatic or renal disease, pregnancy, glaucoma, or penetrating eye injuries.[2]
Abuse of Telazol has been documented.[5] Tiletamine products are classified as Schedule III controlled substances in the United States.[6]
See also
References
- ^ Klockgether, Thomas; Turski, Lechoslaw, Schwarz, Michael, Sontag, Karl-Heinz, Lehmann, John (1 October 1988). "Paradoxical convulsant action of a novel non-competitiveN-methyl-d-aspartate (NMDA) antagonist, tiletamine". Brain Research 461 (2): 343–348. doi:10.1016/0006-8993(88)90265-X.
- ^ a b "Telazol". http://www.drugs.com/vet/telazol.html. Retrieved 5 January 2012.
- ^ Cattet, MR; Caulkett, NA, Lunn, NJ (2003 Jul). "Anesthesia of polar bears using xylazine-zolazepam-tiletamine or zolazepam-tiletamine.". Journal of wildlife diseases 39 (3): 655-64. PMID 14567228.
- ^ Caulkett, NA; Cattet, MR, Cantwell, S, Cool, N, Olsen, W (2000 Jan). "Anesthesia of wood bison with medetomidine-zolazepam/tiletamine and xylazine-zolazepam/tiletamine combinations.". The Canadian veterinary journal. La revue veterinaire canadienne 41 (1): 49-53. PMID 10642872.
- ^ Quail, MT; Weimersheimer, P, Woolf, AD, Magnani, B (2001). "Abuse of telazol: an animal tranquilizer.". Journal of toxicology. Clinical toxicology 39 (4): 399-402. PMID 11527235.
- ^ "Lists of: Scheduling Actions, Controlled Substances, Regulated Chemicals". Drug Enforcement Administration. http://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf. Retrieved 5 January 2012.
External Links
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