MEF2B

MEF2BNB-MEF2B readthrough
PDB rendering based on 1egw.
Available structures PDB 1N6J, 1TQE
Identifiers
Symbols	MEF2BNB-MEF2B; LOC729991-MEF2B; MEF2B
External IDs	OMIM: 600661 MGI: 104526 HomoloGene: 48381 GeneCards: MEF2BNB-MEF2B Gene
Gene Ontology Molecular function • transcription factor activity • transcription coactivator activity • protein binding • sequence-specific DNA binding Cellular component • nucleus Biological process • transcription • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter • muscle development Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4207	17259
Ensembl	ENSG00000213999	n/a
UniProt	Q02080	n/a
RefSeq (mRNA)	NM_005919.3	NM_001045484
RefSeq (protein)	NP_005910	NP_001038949
Location (UCSC)	Chr 19: 19.26 – 19.3 Mb	n/a
PubMed search	[1]	[2]

MADS box transcription enhancer factor 2, polypeptide B (myocyte enhancer factor 2B), also known as MEF2B, is a human gene.

Interactions

MEF2B has been shown to interact with CABIN1.

See also

• Mef2

Further reading

• Yu YT, Breitbart RE, Smoot LB (1992). "Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors.". Genes Dev. 6 (9): 1783–98. doi:10.1101/gad.6.9.1783. PMID 1516833. 
• Pollock R, Treisman R (1992). "Human SRF-related proteins: DNA-binding properties and potential regulatory targets.". Genes Dev. 5 (12A): 2327–41. doi:10.1101/gad.5.12a.2327. PMID 1748287. 
• Hobson GM, Krahe R, Garcia E (1996). "Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23.". Genomics 29 (3): 704–11. doi:10.1006/geno.1995.9007. PMID 8575763. 
• Katoh Y, Molkentin JD, Dave V (1998). "MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expression.". J. Biol. Chem. 273 (3): 1511–8. doi:10.1074/jbc.273.3.1511. PMID 9430690. 
• Iida K, Hidaka K, Takeuchi M (1999). "Expression of MEF2 genes during human cardiac development.". Tohoku J. Exp. Med. 187 (1): 15–23. doi:10.1620/tjem.187.15. PMID 10458488. 
• Youn HD, Sun L, Prywes R, Liu JO (1999). "Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2.". Science 286 (5440): 790–3. doi:10.1126/science.286.5440.790. PMID 10531067. 
• Li M, Linseman DA, Allen MP (2001). "Myocyte enhancer factor 2A and 2D undergo phosphorylation and caspase-mediated degradation during apoptosis of rat cerebellar granule neurons.". J. Neurosci. 21 (17): 6544–52. PMID 11517243. 
• Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Han A, Pan F, Stroud JC (2003). "Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2". Nature 422 (6933): 730–4. doi:10.1038/nature01555. PMID 12700764. 
• Ota T, Suzuki Y, Nishikawa T (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Grimwood J, Gordon LA, Olsen A (2004). "The DNA sequence and biology of human chromosome 19". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824. 
• Konig S, Hinard V, Arnaudeau S (2004). "Membrane hyperpolarization triggers myogenin and myocyte enhancer factor-2 expression during human myoblast differentiation". J. Biol. Chem. 279 (27): 28187–96. doi:10.1074/jbc.M313932200. PMID 15084602. 
• Gerhard DS, Wagner L, Feingold EA (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Han A, He J, Wu Y (2005). "Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2". J. Mol. Biol. 345 (1): 91–102. doi:10.1016/j.jmb.2004.10.033. PMID 15567413. 
• Rual JF, Venkatesan K, Hao T (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Gong X, Tsai SW, Yan B, Rubin LP (2006). "Cooperation between MEF2 and PPARγ in human intestinal β,β-carotene 15,15'-monooxygenase gene expression". BMC Mol. Biol. 7: 7. doi:10.1186/1471-2199-7-7. PMC 1526748. PMID 16504037. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1526748. 

External links

• MeSH MEF2B+protein,+human