Lidoflazine
From Wikipedia, the free encyclopedia
 |
|
|---|---|
| Systematic (IUPAC) name | |
| 2-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]-N-(2,6-dimethylphenyl)acetamide | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 3416-26-0 |
| ATC code | C08EX01 |
| PubChem | CID 3926 |
| UNII | J4ZHN3HBTE  |
| KEGG | D04733 |
| Chemical data | |
| Formula | C30H35F2N3O |
| Mol. mass | 491.615 |
| Physical data | |
| Melt. point | 159–161 °C (318–322 °F) |
| Solubility in water | Almost insoluble in water(<0.01%); Very soluble in chloroform(>50%); mg/mL (20 °C) |
 (what is this?) (verify) |
Lidoflazine is a piperazine calcium channel blocker. It is a coronary vasodilator with some antiarrhythmic action.[1] Lidoflazine was discovered at Janssen Pharmaceutica in 1964.
[edit] Physical properties
[edit] Solubility at room temperature
Extracted from [2]
| Solvent | 0.01
N |
0.1
N |
||
| % | pH | % | pH | |
| Hydrochloric Acid | 0.4 | 3.0 | 0.7 | 1.9 |
| Tartaric Acid | 0.3 | 3.1 | 1.0 | 2.5 |
| Citric Acid | 0.3 | 3.1 | 0.5 | 2.5 |
| Lactic Acid | 0.2 | 3.4 | 0.7 | 2.9 |
| Acetic Acid | 0.1 | 3.5 | 0.4 | 3.8 |
[edit] References
- ^ Schaper, W.K.A.; Xhonneux, R.; Jageneau, A.H.M.; Janssen, P.A.J. (1966). "The cardiovascular pharmacology of lidoflazine, a long-acting coronary vasodilator". Journal of Pharmacology and Experimental Therapeutics 152 (2): 265–274. PMID 5944369. http://jpet.aspetjournals.org/cgi/content/abstract/152/2/265. Retrieved 2009-06-20.
- ^ http://jpet.aspetjournals.org/cgi/content/abstract/152/2/265
- Schaper WK, Xhonneux R, Jageneau AH., Stimulation of the coronary collateral circulation by lidoflazine (R 7904), Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1965 Nov 4;252(1):1-8.
|
 |
This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it. |
