Bazinaprine

Bazinaprine
Systematic (IUPAC) name
	3-{[2-(morpholin-4-yl)ethyl]amino}-6-phenylpyridazine-4-carbonitrile
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	94011-82-2
ATC code	None
PubChem	CID 72119
ChemSpider	65096
Chemical data
Formula	C17H19N5O
Mol. mass	309.366 g/mol
SMILES	eMolecules & PubChem
	InChI InChI=1S/C17H19N5O/c18-13-15-12-16(14-4-2-1-3-5-14)20-21-17(15)19-6-7-22-8-10-23-11-9-22/h1-5,12H,6-11H2,(H,19,21); Key:KRNDIPHOJLIHRI-UHFFFAOYSA-N ;

From Wikipedia, the free encyclopedia

Jump to: navigation, search

Bazinaprine (SR-95,191) is an experimental drug candidate. It is a monoamine oxidase inhibitor (MAOI) which is believed to be useful for the treatment of depression. The drug strongly inhibits type A monoamine oxidase, but only weakly inhibits type B. The effects of the drug are reversible in vivo, but not in vitro.^[1] In studies, the chemical has been shown to not interact in vivo with other neurotransmitter or drug receptor sites.^[2]

[edit] See also

Reversible inhibitor of MAO-A (RIMA)

[edit] References

^ Kan, JP; Steinberg, R; Leclercq, J; Worms, P; Biziere, K (1988). "Monoamine oxidase-inhibiting properties of SR 95191, a new pyridazine derivative, in the rat: Evidence for selective and reversible inhibition of monoamine oxidase type a in vivo but not in vitro". Journal of neurochemistry 50 (4): 1137–44. PMID 3346672.
^ Kan, JP; Steinberg, R; Mouget-Goniot, C; Worms, P; Bizière, K (1987). "SR 95191, a selective inhibitor of type a monoamine oxidase with dopaminergic properties. II. Biochemical characterization of monoamine oxidase inhibition". The Journal of Pharmacology and Experimental Therapeutics 240 (1): 251–8. PMID 3100771. http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=3100771.

[88newderivative-0] Kan, JP; Steinberg, R; Leclercq, J; Worms, P; Biziere, K (1988). "Monoamine oxidase-inhibiting properties of SR 95191, a new pyridazine derivative, in the rat: Evidence for selective and reversible inhibition of monoamine oxidase type a in vivo but not in vitro". Journal of neurochemistry 50 (4): 1137–44. PMID 3346672.

[87MAOI-1] Kan, JP; Steinberg, R; Mouget-Goniot, C; Worms, P; Bizière, K (1987). "SR 95191, a selective inhibitor of type a monoamine oxidase with dopaminergic properties. II. Biochemical characterization of monoamine oxidase inhibition". The Journal of Pharmacology and Experimental Therapeutics 240 (1): 251–8. PMID 3100771. http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=3100771.

[1]

[2]

Dec	JAN	Feb
	29
2011	2012	2013

Bazinaprine

[edit] See also

[edit] References

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Interaction

Toolbox

Print/export