TC-1827
From Wikipedia, the free encyclopedia
| TC-1827 | |
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(S)-N-Methyl-5-(5-pyrimidinyl)-4-penten-2-amine |
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| Identifiers | |
| CAS number | 547741-76-4  |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C10H15N3 |
| Molar mass | 177.25 g mol−1 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
| Infobox references |
TC-1827 is an orally active, selective agonist of the α4β2 nicotinic receptors. Administration of TC-1827 improved memory and learning in a variety in rodents, and increased long-term potentiation in hippocampal slices. In addition, the compound was without significant cardiovascular side effects, except for a small, transient rise in arterial blood pressure. The pro-cognitive effects of TC-1827 last much longer than the short half life (0.2 - 1.0 hours) would suggest.[1]
[edit] References
- ^ Bohme, Georg Andrees (May 2004). "In vitro and in vivo characterization of TC-1827, a novel brain α4β2 nicotinic receptor agonist with pro-cognitive activity". Drug Development Research 62 (1): 26–40. doi:10.1002/ddr.10352.
