F-15,599

F-15,599
Systematic (IUPAC) name
	3-chloro-4-fluorophenyl-[4-fluoro-4-[[(5-methylpyrimidin-2-ylmethyl)amino]methyl]piperidin-1-yl]methanone
Clinical data
Pregnancy cat.	?
Legal status	Uncontrolled
Routes	Oral
Identifiers
CAS number	?
ATC code	None
PubChem	CID ?
Chemical data
Formula	C19H22ClF2N4O
Mol. mass	395.854 g/mol
SMILES	eMolecules & PubChem
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F-15,599 is a very potent and highly selective 5-HT_1A receptor full agonist.^[1]^[2] It displays functional selectivity by strongly activating 5-HT_1A receptors in the prefrontal cortex while having little effect on autoreceptors in the raphe nucleus.^[1]^[2] As a result, it has been touted as a preferential postsynaptic 5-HT_1A receptor agonist and is being investigated as a novel potential antidepressant.^[1]^[2]

[edit] See also

^ ^a ^b ^c Maurel JL, Autin JM, Funes P, Newman-Tancredi A, Colpaert F, Vacher B (October 2007). "High-efficacy 5-HT1A agonists for antidepressant treatment: a renewed opportunity". Journal of Medicinal Chemistry 50 (20): 5024–33. doi:10.1021/jm070714l. PMID 17803293.
^ ^a ^b ^c Newman-Tancredi A, Martel JC, Assié MB, et al. (January 2009). "Signal transduction and functional selectivity of F15599, a preferential post-synaptic 5-HT1A receptor agonist". British Journal of Pharmacology 156 (2): 338–53. doi:10.1111/j.1476-5381.2008.00001.x. PMC 2697830. PMID 19154445. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2697830.

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