IL1F5

Interleukin 36 receptor antagonist
PDB rendering based on 1md6.
Available structures PDB 1md6
Identifiers
Symbols	IL36RN; FIL1; FIL1(DELTA); FIL1D; IL1F5; IL1HY1; IL1L1; IL1RP3; IL36RA; MGC29840
External IDs	OMIM: 605507 MGI: 1859325 HomoloGene: 10453 GeneCards: IL36RN Gene
Gene Ontology Molecular function • cytokine activity • interleukin-1 receptor antagonist activity Cellular component • extracellular region • extracellular space Biological process • negative regulation of cytokine-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	26525	54450
Ensembl	ENSG00000136695	ENSMUSG00000026983
UniProt	Q9UBH0	Q9QYY1
RefSeq (mRNA)	NM_012275.2	NM_019451
RefSeq (protein)	NP_036407.1	NP_062324
Location (UCSC)	Chr 2: 113.82 – 113.82 Mb	Chr 2: 24.13 – 24.14 Mb
PubMed search	[1]	[2]

Interleukin-1 family member 5 is a protein that in humans is encoded by the IL1F5 gene.

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported.

Further reading

• Nicklin MJ, Weith A, Duff GW (1994). "A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes". Genomics 19 (2): 382–4. doi:10.1006/geno.1994.1076. PMID 8188271. 
• Nothwang HG, Strahm B, Denich D et al. (1997). "Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13". Genomics 41 (3): 370–8. doi:10.1006/geno.1997.4654. PMID 9169134. 
• Kumar S, McDonnell PC, Lehr R et al. (2000). "Identification and initial characterization of four novel members of the interleukin-1 family". J. Biol. Chem. 275 (14): 10308–14. doi:10.1074/jbc.275.14.10308. PMID 10744718. 
• Busfield SJ, Comrack CA, Yu G et al. (2000). "Identification and gene organization of three novel members of the IL-1 family on human chromosome 2". Genomics 66 (2): 213–6. doi:10.1006/geno.2000.6184. PMID 10860666. 
• Mulero JJ, Nelken ST, Ford JE (2000). "Organization of the human interleukin-1 receptor antagonist gene IL1HY1". Immunogenetics 51 (6): 425–8. doi:10.1007/s002510050640. PMID 10866108. 
• Barton JL, Herbst R, Bosisio D et al. (2001). "A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities". Eur. J. Immunol. 30 (11): 3299–308. doi:10.1002/1521-4141(200011)30:11<3299::AID-IMMU3299>3.0.CO;2-S. PMID 11093146. 
• Pan G, Risser P, Mao W et al. (2001). "IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp". Cytokine 13 (1): 1–7. doi:10.1006/cyto.2000.0799. PMID 11145836. 
• Lin H, Ho AS, Haley-Vicente D et al. (2001). "Cloning and characterization of IL-1HY2, a novel interleukin-1 family member". J. Biol. Chem. 276 (23): 20597–602. doi:10.1074/jbc.M010095200. PMID 11278614. 
• Debets R, Timans JC, Homey B et al. (2001). "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2". J. Immunol. 167 (3): 1440–6. PMID 11466363. 
• Tazi-Ahnini R, Cox A, McDonagh AJ et al. (2002). "Genetic analysis of the interleukin-1 receptor antagonist and its homologue IL-1L1 in alopecia areata: strong severity association and possible gene interaction". Eur. J. Immunogenet. 29 (1): 25–30. doi:10.1046/j.1365-2370.2002.00271.x. PMID 11841485. 
• Nicklin MJ, Barton JL, Nguyen M et al. (2002). "A sequence-based map of the nine genes of the human interleukin-1 cluster". Genomics 79 (5): 718–25. doi:10.1006/geno.2002.6751. PMID 11991722. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Clark HF, Gurney AL, Abaya E et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697. 
• Zee RY, Fernandez-Ortiz A, Macaya C et al. (2004). "IL-1 cluster genes and occurrence of post-percutaneous transluminal coronary angioplasty restenosis: a prospective, angiography-based evaluation". Atherosclerosis 171 (2): 259–64. doi:10.1016/S0021-9150(03)00294-6. PMID 14644395. 
• Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Colland F, Jacq X, Trouplin V et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442148. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.