Deflazacort
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| Systematic (IUPAC) name | |
| (11β,16β)-21-(acetyloxy)-11-hydroxy-2′-methyl-5′H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Pregnancy cat. | ? |
| Legal status | ? |
| Routes | Oral |
| Pharmacokinetic data | |
| Protein binding | 40% |
| Metabolism | By plasma esterases, to active metabolite |
| Half-life | 1.1–1.9 hours (metabolite) |
| Excretion | Renal (70%) and fecal (30%) |
| Identifiers | |
| CAS number | 14484-47-0 |
| ATC code | H02AB13 |
| PubChem | CID 26709 |
| UNII | KR5YZ6AE4B  |
| KEGG | D03671 |
| Chemical data | |
| Formula | C25H31NO6 |
| Mol. mass | 441.517 g/mol |
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Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant. It is sold in the United Kingdom by Shire under the trade name Calcort,[1] in Brazil as Cortax, Decortil, and Deflanil, and in Honduras as Flezacor.[2] It is not available in the United States.
Deflazacort is a prodrug. Its potency is around 70–90% that of prednisone.[1]
[edit] References
- ^ a b "Calcort". electronic Medicines Compendium. June 11, 2008. http://emc.medicines.org.uk/emc/assets/c/html/displaydoc.asp?documentid=20915. Retrieved on October 28, 2008.
- ^ (Portuguese) "Substâncias: DEFLAZACORT". Centralx. 2008. http://www.bulas.med.br/index.pl?C=A&V=66506F737449443D39333933266163743D73686F7752656164436F6D6D656E7473. Retrieved on October 28, 2008.
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