ATF1

Activating transcription factor 1
PDB rendering based on 1dh3.
Available structures PDB 1dh3
Identifiers
Symbols	ATF1; EWS-ATF1; FUS/ATF-1; TREB36
External IDs	OMIM: 123803 MGI: 1298366 HomoloGene: 3790 GeneCards: ATF1 Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • sequence-specific enhancer binding RNA polymerase II transcription factor activity • protein binding • protein complex binding • sequence-specific DNA binding • protein heterodimerization activity Cellular component • nucleus • nucleoplasm • transcription factor complex Biological process • toll-like receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • transcription, DNA-dependent • regulation of transcription, DNA-dependent • Toll signaling pathway • positive regulation of neuron projection development • response to organic cyclic compound • response to cobalt ion • toll-like receptor 1 signaling pathway • toll-like receptor 2 signaling pathway • toll-like receptor 3 signaling pathway • toll-like receptor 4 signaling pathway • cellular protein complex assembly • innate immune response • positive regulation of DNA replication • positive regulation of transcription from RNA polymerase II promoter • nerve growth factor receptor signaling pathway • stress-activated MAPK cascade Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	466	11908
Ensembl	ENSG00000123268	ENSMUSG00000023027
UniProt	P18846	n/a
RefSeq (mRNA)	NM_005171.4	NM_007497.3
RefSeq (protein)	NP_005162.1	NP_031523.3
Location (UCSC)	Chr 12: 51.16 – 51.21 Mb	Chr 15: 100.06 – 100.09 Mb
PubMed search	[1]	[2]

Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.

See also

• Activating transcription factor

Interactions

ATF1 has been shown to interact with CSNK2A2, Casein kinase 2, alpha 1 and BRCA1. EWS,

Further reading

• Fujimura Y, Ohno T, Siddique H, Lee L, Rao VN, Reddy ES (January 1996). "The EWS-ATF-1 gene involved in malignant melanoma of soft parts with t(12;22) chromosome translocation, encodes a constitutive transcriptional activator". Oncogene 12 (1): 159–67. PMID 8552387. 
• Fujimura Y, Siddique H, Lee L, Rao VN, Reddy ES (October 2001). "EWS-ATF-1 chimeric protein in soft tissue clear cell sarcoma associates with CREB-binding protein and interferes with p53-mediated trans-activation function". Oncogene 20 (46): 6653–9. doi:10.1038/sj.onc.1204684. PMID 11709699. 
• Rehfuss RP, Walton KM, Loriaux MM, Goodman RH (1991). "The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A.". J. Biol. Chem. 266 (28): 18431–4. PMID 1655749. 
• Yoshimura T, Fujisawa J, Yoshida M (1990). "Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain.". EMBO J. 9 (8): 2537–42. PMC 552284. PMID 2196176. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=552284. 
• Hai TW, Liu F, Coukos WJ, Green MR (1990). "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.". Genes Dev. 3 (12B): 2083–90. doi:10.1101/gad.3.12b.2083. PMID 2516827. 
• Pongubala JM, Atchison ML (1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate the activity of the immunoglobulin kappa 3' enhancer.". J. Biol. Chem. 270 (17): 10304–13. doi:10.1074/jbc.270.17.10304. PMID 7730336. 
• Liu F, Thompson MA, Wagner S, et al. (1993). "Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation.". J. Biol. Chem. 268 (9): 6714–20. PMID 8384217. 
• Dorsey MJ, Tae HJ, Sollenberger KG, et al. (1996). "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family.". Oncogene 11 (11): 2255–65. PMID 8570175. 
• Sun P, Lou L, Maurer RA (1996). "Regulation of activating transcription factor-1 and the cAMP response element-binding protein by Ca2+/calmodulin-dependent protein kinases type I, II, and IV.". J. Biol. Chem. 271 (6): 3066–73. doi:10.1074/jbc.271.6.3066. PMID 8621702. 
• Shimomura A, Ogawa Y, Kitani T, et al. (1996). "Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein.". J. Biol. Chem. 271 (30): 17957–60. doi:10.1074/jbc.271.30.17957. PMID 8663317. 
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• Kobayashi M, Shimomura A, Hagiwara M, Kawakami K (1997). "Phosphorylation of ATF-1 enhances its DNA binding and transcription of the Na,K-ATPase alpha 1 subunit gene promoter.". Nucleic Acids Res. 25 (4): 877–82. doi:10.1093/nar/25.4.877. PMC 146500. PMID 9016641. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=146500. 
• Soubt MK, Marksitzer R, Menoud PA, Nagamine Y (1998). "Role of tissue-specific transcription factor LFB3 in a cyclic AMP-responsive enhancer of the urokinase-type plasminogen activator gene in LLC-PK1 cells.". Mol. Cell. Biol. 18 (8): 4698–706. PMC 109056. PMID 9671480. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=109056. 
• Yamaguchi Y, Wada T, Suzuki F, et al. (1998). "Casein kinase II interacts with the bZIP domains of several transcription factors.". Nucleic Acids Res. 26 (16): 3854–61. doi:10.1093/nar/26.16.3854. PMC 147779. PMID 9685505. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=147779. 
• Pellín A, Monteagudo C, López-Ginés C, et al. (1999). "New type of chimeric fusion product between the EWS and ATFI genes in clear cell sarcoma (malignant melanoma of soft parts).". Genes Chromosomes Cancer 23 (4): 358–60. doi:10.1002/(SICI)1098-2264(199812)23:4<358::AID-GCC11>3.0.CO;2-3. PMID 9824209. 
• Kabe Y, Goto M, Shima D, et al. (1999). "The role of human MBF1 as a transcriptional coactivator.". J. Biol. Chem. 274 (48): 34196–202. doi:10.1074/jbc.274.48.34196. PMID 10567391. 
• Sawada J, Simizu N, Suzuki F, et al. (2000). "Synergistic transcriptional activation by hGABP and select members of the activation transcription factor/cAMP response element-binding protein family.". J. Biol. Chem. 274 (50): 35475–82. doi:10.1074/jbc.274.50.35475. PMID 10585419. 
• Houvras Y, Benezra M, Zhang H, et al. (2000). "BRCA1 physically and functionally interacts with ATF1.". J. Biol. Chem. 275 (46): 36230–7. doi:10.1074/jbc.M002539200. PMID 10945975. 
• Knöfler M, Saleh L, Bauer S, et al. (2000). "Promoter elements and transcription factors involved in differentiation-dependent human chorionic gonadotrophin-alpha messenger ribonucleic acid expression of term villous trophoblasts.". Endocrinology 141 (10): 3737–48. doi:10.1210/en.141.10.3737. PMID 11014230. 
• Arthur JS, Cohen P (2000). "MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells.". FEBS Lett. 482 (1-2): 44–8. doi:10.1016/S0014-5793(00)02031-7. PMID 11018520. 
• Andreucci JJ, Grant D, Cox DM, et al. (2002). "Composition and function of AP-1 transcription complexes during muscle cell differentiation.". J. Biol. Chem. 277 (19): 16426–32. doi:10.1074/jbc.M110891200. PMID 11877423. 

External links

• MeSH ATF1+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.