SREBF2

Sterol regulatory element binding transcription factor 2
	; PDB rendering based on 1ukl.
Available structures
PDB	1ukl
Identifiers
Symbols	SREBF2; SREBP2; bHLHd2
External IDs	OMIM: 600481 MGI: 107585 HomoloGene: 20966 GeneCards: SREBF2 Gene
Gene Ontology
Molecular function	• C-8 sterol isomerase activity; • chromatin binding; • sequence-specific DNA binding transcription factor activity; • protein binding; • protein C-terminus binding; • sequence-specific DNA binding;
Cellular component	• Golgi membrane; • nucleus; • cytoplasm; • endoplasmic reticulum; • endoplasmic reticulum membrane; • microsome; • Golgi apparatus; • ER to Golgi transport vesicle membrane; • membrane; • integral to membrane; • dendrite; • cytoplasmic vesicle; • SREBP-SCAP-Insig complex;
Biological process	• lipid metabolic process; • spermatogenesis; • aging; • steroid metabolic process; • cholesterol metabolic process; • response to hormone stimulus; • response to lead ion; • response to lipid; • positive regulation of transcription via sterol regulatory element binding; • response to drug; • positive regulation of transcription from RNA polymerase II promoter;
	Sources: Amigo / QuickGO
Orthologs

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Sterol regulatory element-binding protein 2 (SREBP-2) also known as sterol regulatory element binding transcription factor 2 (SREBF2) is a protein that in humans is encoded by the SREBF2 gene.^[1]

[edit] Function

This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix leucine zipper (bHLH-Zip) domain.^[2]

[edit] Interactions

SREBF2 has been shown to interact with INSIG1^[3]^[4] and CREB-binding protein.^[5]

[edit] See also

Sterol regulatory element-binding protein

[edit] References

^ Hua X, Yokoyama C, Wu J, Briggs MR, Brown MS, Goldstein JL, Wang X (Jan 1994). "SREBP-2, a second basic helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element". Proc Natl Acad Sci U S A 90 (24): 11603–11607. doi:10.1073/pnas.90.24.11603. PMC 48032. PMID 7903453. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=48032.
^ "Entrez Gene: SREBF2 sterol regulatory element binding transcription factor 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6721.
^ Dobrosotskaya, Irina Y; Goldstein Joseph L, Brown Michael S, Rawson Robert B (Sep. 2003). "Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs". J. Biol. Chem. (United States) 278 (37): 35837–35843. doi:10.1074/jbc.M306476200. ISSN 0021-9258. PMID 12842885.
^ Yang, Tong; Espenshade Peter J, Wright Michael E, Yabe Daisuke, Gong Yi, Aebersold Ruedi, Goldstein Joseph L, Brown Michael S (Aug. 2002). "Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER". Cell (United States) 110 (4): 489–500. doi:10.1016/S0092-8674(02)00872-3. ISSN 0092-8674. PMID 12202038.
^ Oliner, J D; Andresen J M, Hansen S K, Zhou S, Tjian R (Nov. 1996). "SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein". Genes Dev. (UNITED STATES) 10 (22): 2903–2911. doi:10.1101/gad.10.22.2903. ISSN 0890-9369. PMID 8918891.

[edit] Further reading

Osborne TF (2001). "CREating a SCAP-less liver keeps SREBPs pinned in the ER membrane and prevents increased lipid synthesis in response to low cholesterol and high insulin". Genes Dev. 15 (15): 1873–1878. doi:10.1101/gad.916601. PMID 11485982.
Szolkiewicz M, Chmielewski M, Nogalska A et al. (2007). "The potential role of sterol regulatory element binding protein transcription factors in renal injury". Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 17 (1): 62–5. doi:10.1053/j.jrn.2006.10.009. PMID 17198935.
Hua X, Wu J, Goldstein JL et al. (1995). "Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13". Genomics 25 (3): 667–73. doi:10.1016/0888-7543(95)80009-B. PMID 7759101.
Yokoyama C, Wang X, Briggs MR et al. (1993). "SREBP-1, a basic helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene". Cell 75 (1): 187–97. doi:10.1016/S0092-8674(05)80095-9. PMID 8402897.
Wang X, Zelenski NG, Yang J et al. (1996). "Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis". EMBO J. 15 (5): 1012–20. PMC 449996. PMID 8605870. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=449996.
Hua X, Sakai J, Brown MS, Goldstein JL (1996). "Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane". J. Biol. Chem. 271 (17): 10379–10384. doi:10.1074/jbc.271.17.10379. PMID 8626610.
Pai JT, Brown MS, Goldstein JL (1996). "Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins". Proc. Natl. Acad. Sci. U.S.A. 93 (11): 5437–5442. doi:10.1073/pnas.93.11.5437. PMC 39264. PMID 8643593. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=39264.
Sato R, Inoue J, Kawabe Y et al. (1996). "Sterol-dependent transcriptional regulation of sterol regulatory element-binding protein-2". J. Biol. Chem. 271 (43): 26461–4. doi:10.1074/jbc.271.43.26461. PMID 8900111.
Oliner JD, Andresen JM, Hansen SK et al. (1996). "SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein". Genes Dev. 10 (22): 2903–11. doi:10.1101/gad.10.22.2903. PMID 8918891.
Miserez AR, Cao G, Probst LC, Hobbs HH (1997). "Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2)". Genomics 40 (1): 31–40. doi:10.1006/geno.1996.4525. PMID 9070916.
Duncan EA, Brown MS, Goldstein JL, Sakai J (1997). "Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2". J. Biol. Chem. 272 (19): 12778–12785. doi:10.1074/jbc.272.19.12778. PMID 9139737.
Harris IR, Farrell AM, Holleran WM et al. (1998). "Parallel regulation of sterol regulatory element binding protein-2 and the enzymes of cholesterol and fatty acid synthesis but not ceramide synthesis in cultured human keratinocytes and murine epidermis". J. Lipid Res. 39 (2): 412–22. PMID 9508001.
Kan HY, Pissios P, Chambaz J, Zannis VI (1999). "DNA binding specificity and transactivation properties of SREBP-2 bound to multiple sites on the human apoA-II promoter". Nucleic Acids Res. 27 (4): 1104–1117. doi:10.1093/nar/27.4.1104. PMC 148292. PMID 9927745. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=148292.
Seidah NG, Mowla SJ, Hamelin J et al. (1999). "Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization". Proc. Natl. Acad. Sci. U.S.A. 96 (4): 1321–6. doi:10.1073/pnas.96.4.1321. PMC 15461. PMID 9990022. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=15461.
Nagoshi E, Imamoto N, Sato R, Yoneda Y (1999). "Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip". Mol. Biol. Cell 10 (7): 2221–33. PMC 25438. PMID 10397761. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=25438.
Dunham I, Shimizu N, Roe BA et al. (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
DeBose-Boyd RA, Brown MS, Li WP et al. (2000). "Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi". Cell 99 (7): 703–12. doi:10.1016/S0092-8674(00)81668-2. PMID 10619424.
Kotzka J, Müller-Wieland D, Roth G et al. (2000). "Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade". J. Lipid Res. 41 (1): 99–108. PMID 10627507.
Yang T, Goldstein JL, Brown MS (2000). "Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP.SREBP exit from endoplasmic reticulum". J. Biol. Chem. 275 (38): 29881–29886. doi:10.1074/jbc.M005439200. PMID 10896675.

[edit] External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on chromosome 22 is a stub. You can help Wikipedia by expanding it.

[pmid7903453-0] Hua X, Yokoyama C, Wu J, Briggs MR, Brown MS, Goldstein JL, Wang X (Jan 1994). "SREBP-2, a second basic helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element". Proc Natl Acad Sci U S A 90 (24): 11603–11607. doi:10.1073/pnas.90.24.11603. PMC 48032. PMID 7903453. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=48032.

[entrez-1] "Entrez Gene: SREBF2 sterol regulatory element binding transcription factor 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6721.

[pmid12842885-2] Dobrosotskaya, Irina Y; Goldstein Joseph L, Brown Michael S, Rawson Robert B (Sep. 2003). "Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs". J. Biol. Chem. (United States) 278 (37): 35837–35843. doi:10.1074/jbc.M306476200. ISSN 0021-9258. PMID 12842885.

[pmid12202038-3] Yang, Tong; Espenshade Peter J, Wright Michael E, Yabe Daisuke, Gong Yi, Aebersold Ruedi, Goldstein Joseph L, Brown Michael S (Aug. 2002). "Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER". Cell (United States) 110 (4): 489–500. doi:10.1016/S0092-8674(02)00872-3. ISSN 0092-8674. PMID 12202038.

[pmid8918891-4] Oliner, J D; Andresen J M, Hansen S K, Zhou S, Tjian R (Nov. 1996). "SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein". Genes Dev. (UNITED STATES) 10 (22): 2903–2911. doi:10.1101/gad.10.22.2903. ISSN 0890-9369. PMID 8918891.

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Nov	DEC	Jan
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SREBF2

Contents

[edit] Function

[edit] Interactions

[edit] See also

[edit] References

[edit] Further reading

[edit] External links

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