MYB (gene)

V-myb myeloblastosis viral oncogene homolog (avian)
PDB rendering based on 1guu.
Available structures PDB 1guu, 1gv2, 1gv5, 1gvd, 1h88, 1h89, 1h8a, 1idy, 1idz, 1mbe, 1mbf, 1mbg, 1mbh, 1mbj, 1mbk, 1mse, 1msf
Identifiers
Symbols	MYB; Cmyb; c-myb; c-myb_CDS; efg
External IDs	OMIM: 189990 MGI: 97249 HomoloGene: 31311 GeneCards: MYB Gene
Gene Ontology Molecular function • DNA binding • protein binding Cellular component • nucleus • nuclear matrix Biological process • negative regulation of transcription from RNA polymerase II promoter • chromatin remodeling • regulation of transcription, DNA-dependent • blood coagulation • positive regulation of T-helper cell differentiation • negative regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter • positive regulation of histone H3-K4 methylation • positive regulation of histone H3-K9 methylation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4602	17863
Ensembl	ENSG00000118513	ENSMUSG00000019982
UniProt	P10242	Q8BU24
RefSeq (mRNA)	NM_001130172.1	NM_033597
RefSeq (protein)	NP_001123644.1	NP_291075
Location (UCSC)	Chr 6: 135.5 – 135.54 Mb	Chr 10: 20.84 – 20.88 Mb
PubMed search	[1]	[2]

Myb proto-oncogene protein also known as transcriptional activator Myb is a protein that in humans is encoded by the MYB gene.

Function

Myb proto-oncogene protein is a member of the MYB (myeloblastosis) family of transcription factors. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis.

Further reading

• Oh IH, Reddy EP (1999). "The myb gene family in cell growth, differentiation and apoptosis.". Oncogene 18 (19): 3017–33. doi:10.1038/sj.onc.1202839. PMID 10378697. 
• Nicolaides NC, Gualdi R, Casadevall C, et al. (1991). "Positive autoregulation of c-myb expression via Myb binding sites in the 5' flanking region of the human c-myb gene.". Mol. Cell. Biol. 11 (12): 6166–76. PMC 361795. PMID 1944282. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=361795. 
• Kalkbrenner F, Guehmann S, Moelling K (1990). "Transcriptional activation by human c-myb and v-myb genes.". Oncogene 5 (5): 657–61. PMID 2189102. 
• Westin EH, Gorse KM, Clarke MF (1990). "Alternative splicing of the human c-myb gene.". Oncogene 5 (8): 1117–24. PMID 2202948. 
• Dasgupta P, Reddy EP (1990). "Identification of alternatively spliced transcripts for human c-myb: molecular cloning and sequence analysis of human c-myb exon 9A sequences.". Oncogene 4 (12): 1419–23. PMID 2687764. 
• Janssen JW, Vernole P, de Boer PA, et al. (1986). "Sublocalization of c-myb to 6q21----q23 by in situ hybridization and c-myb expression in a human teratocarcinoma with 6q rearrangements.". Cytogenet. Cell Genet. 41 (3): 129–35. doi:10.1159/000132217. PMID 3007038. 
• Slamon DJ, Boone TC, Murdock DC, et al. (1986). "Studies of the human c-myb gene and its product in human acute leukemias.". Science 233 (4761): 347–51. doi:10.1126/science.3014652. PMID 3014652. 
• Majello B, Kenyon LC, Dalla-Favera R (1987). "Human c-myb protooncogene: nucleotide sequence of cDNA and organization of the genomic locus.". Proc. Natl. Acad. Sci. U.S.A. 83 (24): 9636–40. doi:10.1073/pnas.83.24.9636. PMC 387195. PMID 3540945. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=387195. 
• Szczylik C, Skorski T, Ku DH, et al. (1993). "Regulation of proliferation and cytokine expression of bone marrow fibroblasts: role of c-myb.". J. Exp. Med. 178 (3): 997–1005. doi:10.1084/jem.178.3.997. PMC 2191153. PMID 7688794. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2191153. 
• Krieg J, Oelgeschläger M, Janknecht R, Lüscher B (1995). "High affinity DNA binding of native full length c-Myb and differential proteolytic sensitivity of its N- and C-terminal domains.". Oncogene 10 (11): 2221–8. PMID 7784067. 
• Jacobs SM, Gorse KM, Westin EH (1994). "Identification of a second promoter in the human c-myb proto-oncogene.". Oncogene 9 (1): 227–35. PMID 8302584. 
• Favier D, Gonda TJ (1994). "Detection of proteins that bind to the leucine zipper motif of c-Myb.". Oncogene 9 (1): 305–11. PMID 8302594. 
• Glaser R, Lafuse WP, Bonneau RH, et al. (1993). "Stress-associated modulation of proto-oncogene expression in human peripheral blood leukocytes.". Behav. Neurosci. 107 (3): 525–9. doi:10.1037/0735-7044.107.3.525. PMID 8329139. 
• Dash AB, Orrico FC, Ness SA (1996). "The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb.". Genes Dev. 10 (15): 1858–69. doi:10.1101/gad.10.15.1858. PMID 8756344. 
• Vorbrueggen G, Lovrić J, Moelling K (1997). "Functional analysis of phosphorylation at serine 532 of human c-Myb by MAP kinase.". Biol. Chem. 377 (11): 721–30. PMID 8960373. 
• Tavner FJ, Simpson R, Tashiro S, et al. (1998). "Molecular cloning reveals that the p160 Myb-binding protein is a novel, predominantly nucleolar protein which may play a role in transactivation by Myb.". Mol. Cell. Biol. 18 (2): 989–1002. PMC 108811. PMID 9447996. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=108811. 
• Hedge SP, Kumar A, Kurschner C, Shapiro LH (1998). "c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation.". Mol. Cell. Biol. 18 (5): 2729–37. PMC 110652. PMID 9566892. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=110652. 
• Leverson JD, Koskinen PJ, Orrico FC, et al. (1998). "Pim-1 kinase and p100 cooperate to enhance c-Myb activity.". Mol. Cell 2 (4): 417–25. doi:10.1016/S1097-2765(00)80141-0. PMID 9809063. 
• Thompson MA, Rosenthal MA, Ellis SL, et al. (1998). "c-Myb down-regulation is associated with human colon cell differentiation, apoptosis, and decreased Bcl-2 expression.". Cancer Res. 58 (22): 5168–75. PMID 9823328. 
• Verbeek W, Gombart AF, Chumakov AM, et al. (1999). "C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters.". Blood 93 (10): 3327–37. PMID 10233885. 

External links

• MeSH MYB+protein,+human
• Drosophila Myb oncogene-like - The Interactive Fly

This article incorporates text from the United States National Library of Medicine, which is in the public domain.