FOSL1

FOS-like antigen 1
Identifiers
Symbols	FOSL1; FRA; FRA1; fra-1
External IDs	OMIM: 136515 MGI: 107179 HomoloGene: 3967 GeneCards: FOSL1 Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • protein binding • sequence-specific DNA binding • protein dimerization activity Cellular component • nucleus • microsome • cytosol • synaptosome • presynaptic membrane Biological process • regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • chemotaxis • cellular defense response • female pregnancy • learning • positive regulation of cell proliferation • negative regulation of cell proliferation • response to mechanical stimulus • response to virus • response to gravity • response to organic cyclic compound • cellular response to extracellular stimulus • response to progesterone stimulus • response to cytokine stimulus • response to drug • response to hydrogen peroxide • positive regulation of apoptosis • positive regulation of cell cycle • positive regulation of transcription from RNA polymerase II promoter during mitosis • response to corticosterone stimulus • response to cAMP Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8061	14283
Ensembl	ENSG00000175592	ENSMUSG00000024912
UniProt	P15407	Q3UMA0
RefSeq (mRNA)	NM_005438	NM_010235.2
RefSeq (protein)	NP_005429	NP_034365.1
Location (UCSC)	Chr 11: 65.66 – 65.67 Mb	Chr 19: 5.45 – 5.46 Mb
PubMed search	[1]	[2]

Fos-related antigen 1 is a protein that in humans is encoded by the FOSL1 gene.

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.

Interactions

FOSL1 has been shown to interact with USF1 (human gene) and C-jun.

See also

• AP-1 (transcription factor)

Further reading

• Herdegen T, Leah JD (1999). "Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins.". Brain Res. Brain Res. Rev. 28 (3): 370–490. doi:10.1016/S0165-0173(98)00018-6. PMID 9858769. 
• Reddy SP, Mossman BT (2002). "Role and regulation of activator protein-1 in toxicant-induced responses of the lung.". Am. J. Physiol. Lung Cell Mol. Physiol. 283 (6): L1161–78. doi:10.1152/ajplung.00140.2002. PMID 12424143. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Tsuchiya H, Fujii M, Niki T, et al. (1993). "Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals". J. Virol. 67 (12): 7001–7. PMC 238160. PMID 8230424. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=238160. 
• Sinke RJ, Tanigami A, Nakamura Y, Geurts van Kessel A (1994). "Reverse mapping of the gene encoding the human fos-related antigen-1 (fra-1) within chromosome band 11q13". Genomics 18 (1): 165. doi:10.1006/geno.1993.1447. PMID 8276409. 
• Courseaux A, Grosgeorge J, Gaudray P, et al. (1997). "Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1)". Genomics 37 (3): 354–65. PMID 8938448. 
• Arts J, Herr I, Lansink M, et al. (1997). "Cell-type specific DNA-protein interactions at the tissue-type plasminogen activator promoter in human endothelial and HeLa cells in vivo and in vitro". Nucleic Acids Res. 25 (2): 311–7. doi:10.1093/nar/25.2.311. PMC 146448. PMID 9016559. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=146448. 
• Pognonec P, Boulukos KE, Aperlo C, et al. (1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity". Oncogene 14 (17): 2091–8. doi:10.1038/sj.onc.1201046. PMID 9160889. 
• Smith CM, Ma NS, Nowak NJ, et al. (1997). "A 3-Mb contig from D11S987 to MLK3, a gene-rich region in 11q13". Genome Res. 7 (8): 835–42. doi:10.1101/gr.7.8.835. PMC 310665. PMID 9267807. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310665. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Puntschart A, Wey E, Jostarndt K, et al. (1998). "Expression of fos and jun genes in human skeletal muscle after exercise". Am. J. Physiol. 274 (1 Pt 1): C129–37. PMID 9458721. 
• Finzer P, Soto U, Delius H, et al. (2000). "Differential transcriptional regulation of the monocyte-chemoattractant protein-1 (MCP-1) gene in tumorigenic and non-tumorigenic HPV 18 positive cells: the role of the chromatin structure and AP-1 composition". Oncogene 19 (29): 3235–44. doi:10.1038/sj.onc.1203643. PMID 10918580. 
• Udalova IA, Kwiatkowski D (2001). "Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region". Biochem. Biophys. Res. Commun. 289 (1): 25–33. doi:10.1006/bbrc.2001.5929. PMID 11708771. 
• Jardine H, MacNee W, Donaldson K, Rahman I (2002). "Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1". J. Biol. Chem. 277 (24): 21158–66. doi:10.1074/jbc.M112145200. PMID 11912197. 
• Wang HL, Wang J, Xiao SY, et al. (2002). "Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin". Int. J. Cancer 101 (4): 301–10. doi:10.1002/ijc.10630. PMID 12209953. 
• Bergman MR, Cheng S, Honbo N, et al. (2003). "A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers". Biochem. J. 369 (Pt 3): 485–96. doi:10.1042/BJ20020707. PMC 1223099. PMID 12371906. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1223099. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 

External links

• MeSH FOSL1+protein,+human
• FactorBook FOSL1

This article incorporates text from the United States National Library of Medicine, which is in the public domain.