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From Wikipedia, the free encyclopedia
| MAX dimerization protein 4 | ||||||||
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| Identifiers | ||||||||
| Symbols | MXD4; MAD4; MST149; MSTP149; bHLHc12 | |||||||
| External IDs | MGI: 104991 HomoloGene: 4712 GeneCards: MXD4 Gene | |||||||
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| RNA expression pattern | ||||||||
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| More reference expression data | ||||||||
| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 10608 | 17122 | ||||||
| Ensembl | ENSG00000123933 | ENSMUSG00000037235 | ||||||
| UniProt | Q14582 | n/a | ||||||
| RefSeq (mRNA) | NM_006454 | NM_010753.2 | ||||||
| RefSeq (protein) | NP_006445 | NP_034883.2 | ||||||
| Location (UCSC) | Chr 4: 2.25 – 2.26 Mb |
Chr 5: 34.52 – 34.53 Mb |
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| PubMed search | [1] | [2] |
Max-interacting transcriptional repressor MAD4 is a protein that in humans is encoded by the MXD4 gene.[1][2]
This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues.[2]
[edit] References
- ^ Hurlin PJ, Queva C, Koskinen PJ, Steingrimsson E, Ayer DE, Copeland NG, Jenkins NA, Eisenman RN (Jan 1996). "Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation". EMBO J 14 (22): 5646–59. PMC 394680. PMID 8521822. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=394680.
- ^ a b "Entrez Gene: MXD4 MAX dimerization protein 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10608.
[edit] Further reading
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Marcotte R, Chen JM, Huard S, Wang E (2006). "c-Myc creates an activation loop by transcriptionally repressing its own functional inhibitor, hMad4, in young fibroblasts, a loop lost in replicatively senescent fibroblasts.". J. Cell. Biochem. 96 (5): 1071–85. doi:10.1002/jcb.20503. PMID 16167342.
- Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin.". J. Steroid Biochem. Mol. Biol. 94 (1-3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967.
- Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Jiang DJ, Yu HX, Hexige SY, et al. (2004). "Human liver specific transcriptional factor TCP10L binds to MAD4.". J. Biochem. Mol. Biol. 37 (4): 402–7. PMID 15469726.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Kime L, Wright SC (2003). "Mad4 is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc.". Biochem. J. 370 (Pt 1): 291–8. doi:10.1042/BJ20021679. PMC 1223147. PMID 12418961. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1223147.
- Cairo S, Merla G, Urbinati F, et al. (2001). "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network.". Hum. Mol. Genet. 10 (6): 617–27. doi:10.1093/hmg/10.6.617. PMID 11230181.
- Billin AN, Eilers AL, Queva C, Ayer DE (2000). "Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors.". J. Biol. Chem. 274 (51): 36344–50. doi:10.1074/jbc.274.51.36344. PMID 10593926.
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